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The effect of omitting axillary dissection and the impact of radiotherapy on patients with breast cancer sentinel node macrometastases: a cohort study following the ACOSOG Z0011 and AMAROS trials

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Abstract

Purpose

To report the outcomes of implementing the ACOSOG Z0011 and AMAROS trials relevant to clinical practice, and to define target groups in whom to avoid or recommend axillary radiotherapy (ART). We also aimed to analyse the reduction in morbidity when axillary lymph node dissection (ALND) was omitted.

Methods

A retrospective cohort study of T1–T2 patients with macrometastases at sentinel lymph node (SLN) who were treated between 2011 and 2020. Breast surgery included either lumpectomy or mastectomy. Patients with ≤ 2 positive SLN were divided into two cohorts by whether they received ART or not. Survival outcomes and morbidity were analysed by Kaplan–Meyer curves and Cox-regression, respectively.

Results

260 pN1a patients were included and ALND was avoided in 167 (64.2%). According the Z0011 results, 72 (43.1%) received no further ART; and based on AMAROS criteria 95 (56.9%) received ART. Median follow-up was 54 months. The 5-year overall survival was 96.8% in the non-RT cohort and 93.4% in the RT cohort (p = 0.19), while the respective 5-year disease-free survivals were 100% and 92.3% (p = 1.06). Lymphedema developed in 3.6% of patients after SLNB versus 43% after ALND (OR 20.25; 95%CI 8.13–50.43). Decreased upper-extremity range of motion appeared in 8.4% of patients after SLNB versus 31.2% after ALND (OR 4.95; 95%CI 2.45–9.98%).

Conclusions

Our study confirms that omitting ALND is safe and has high survival rates in patients with T1–T2 tumours and ≤ 2 positive SLNs. Adding ART could be a treatment option for patients who present other risk factors. Avoiding ALND with or without ART was associated with significantly less arm morbidity.

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Acknowledgements

We thank Michael Maudsley, MSc, for language revision.

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Authors and Affiliations

  1. Bellvitge University Hospital: Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain

    Carlos Ortega Expósito, Catalina Falo, Sonia Pernas, Samuel Pérez Carton, Miguel Gil Gil, Raul Ortega, Héctor Pérez Montero, Agostina Stradella, Evelyn Martinez, Maria Laplana, Sira Salinas, Ana Luzardo, Teresa Soler, Maria Eulalia Fernández Montoli, Juan Azcarate, Anna Guma, Anna Petit, Ana Benitez, Maite Bajen, Jose G. Reyes Junca, Miriam Campos, Raquel Ruiz, Jordi Ponce, Maria J. Pla & Amparo García Tejedor

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Correspondence to Carlos Ortega Expósito.

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Ortega Expósito, C., Falo, C., Pernas, S. et al. The effect of omitting axillary dissection and the impact of radiotherapy on patients with breast cancer sentinel node macrometastases: a cohort study following the ACOSOG Z0011 and AMAROS trials. Breast Cancer Res Treat 189, 111–120 (2021). https://doi.org/10.1007/s10549-021-06274-9

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