Abstract
We describe a rare case of a tumor resembling dysembryoplastic neuroepithelial tumor. A 3-year-old girl had a generalized convulsion as the initial symptom, without other neurological deficits. Computed tomography showed a hypodense lesion with calcific hyperdensity in the left frontal lobe associated with deformity of the overlying calvarium. Four months later, she had a second seizure, and computed tomographic scan showed that the lesion had increased in size. Subtotal removal of the tumor was performed, and the postoperative course was uneventful without radiation therapy. Histological examination revealed a cortical lesion in which an oligodendrocyte-like area and an astrocyte-like area with cytological atypia were observed. Although the clinical course and the radiological findings closely resembled those of dysembryoplastic neuroepithelial tumor, specific glioneuronal elements were not found histologically. Daumas-Duport reported a complex form of dysembryoplastic neuroepithelial tumor that contained glial nodules in addition to a specific glioneuronal element. The histological findings of the glial nodules in this case were quite similar to those she described. We conclude that this could be an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor without a specific glioneuronal element.
Similar content being viewed by others
References
Daumaous-Duport C, Scheithauer BW, Chodkieweis JP, et al (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Neurosurgery 23:545–556
Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system, 2nd edn. Springer, New York, p 23
Prayson RA, Morris HH, Estes ML (1996) Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study of 11 tumors including MIB 1 immunoreactivity. Clin Neuropathol 15:47–53
Ostertun B, Wolf HK, Campos MG, et al (1996) Dysembryoplastic neuroepithelial tumor: MR and CT evaluation. Am J Neuroradiol 17:419–430
Daumaous-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathol 3:283–295
Iwanaga K, Takahashi H, Kameyama S, et al (1995) Dysembryoplastic neuroepithelial tumor: report of a case without typical glioneuronal elements. Acta Neuropathol 89:284–289
Adachi H, Shinohara C, Ono Y, et al (1995) Dysembryoplastic neuroepithelial tumor: a case report. JOSPA 32:41–46 (in Japanese)
Chang BC, Chen CY, Wei YH, et al (1996) Mesial temporal dysembryoplastic neuroepithelial tumor mimicking oligodendroglioma. Chang Gung Med J 19:382–387
Kimura S, Kobayashi T, Hara M (1996) A case of dysembryoplastic neuroepithelial tumor of the parietal lobe with characteristic magnetic resonance imaging. Acta Paediatr Japon 38:168–171
Kuroiwa T, Bergey GK, Rothman MI, et al (1995) Radiologic appearance of the dysembryoplastic neuroepithelial tumor. Radiology 197:233–238
Yamaguchi N, Oonishi H, Tachibana O, et al (1998) An enlarging dysembryoplastic neuroepithelial tumor during a 6-year period. No Shinkei Geka 26:1097–1101 (in Japanese)
Hanavar M, Janota I, Polkey CE (1999) Histological heterogeneity of dysembryoplastic neuroepithelial tumour: identification and differential diagnosis in a series of 74 cases. Histopathology 34:342–356
Author information
Authors and Affiliations
Additional information
This case was registered at the Japan Brain Tumor Reference Center (No. 98-012)
Rights and permissions
About this article
Cite this article
Nakatsuka, M., Mizuno, S., Kimura, T. et al. A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor with rapid growth. Brain Tumor Pathol 17, 41–45 (2000). https://doi.org/10.1007/BF02478917
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02478917