Skip to main content
SpringerLink
Log in

Urinary excretion of calcium, magnesium, oxalate and citrate in duodenal ulcer patients. preliminary results before and up to five years after highly selective vagotomy

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

The urinary excretion of calcium, oxalate, citrate and magnesium, and the relative saturation products in urine of either calcium oxalate or calcium phosphate, were determined in male duodenal ulcer (DU) patients preoperatively (n=60), and 1 and 5 years following highly selective vagotomy (HSV), and in male healthy controls (n=30). In DU before HSV citrate and magnesium were lowered, oxalate was in the low normal range and calcium was normal. The calcium oxalate product was lower than in controls, while the calcium phosphate product was unchanged. Within 5 years HSV normalized urinary citrate and oxalate, but not urinary magnesium, and the median urinary pH was lower than pre-operatively. There thus results a normal product for calcium oxalate, but a reduced one for calcium phosphate. It is suggested that: (1) unoperated DU patients have a urine composition similar to that cxhibited in normocalciuric recurrent calcium urolithiasis; (2) this spectrum of urinary constituents may be changed by HSV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Frame B, Haubrich W (1960) Peptic ulcer and hyperparathyroidism. Arch Int Med 105:536

    Google Scholar 

  2. Smith LH, Fromm H, Hofmann AF (1972) Acquired hyperparathyroidism. nephrolithiasis, and intestinal disease; description of a syndrome. N Engl J Med 186:1371

    Google Scholar 

  3. Gelsayd EA, Breuer RI, Krsner JB (1968) Nephrolithiasis in inflammatory bowel disease. Am J Dig Dis 13:1027

    PubMed  Google Scholar 

  4. Halverson JD, Schell RJ, Gentry K, Alpers DH (1980) Jejunoileal bypass. Late metabolic sequelae and weight gain. Am J Surg 140:347

    PubMed  Google Scholar 

  5. Ljunghall S (1978) Incidence and natural history of renal stone disease and its relationship to calcium metabolism. Eur Urol 4:424

    PubMed  Google Scholar 

  6. Stauffer JO (1977) Hyperoxaluria and calcium oxalate nephrolithiasis after jejunoileal bypass. Am J Clin Nutr 30:64

    PubMed  Google Scholar 

  7. Caspary WF, Tönissen J (1978) Enterale Hyperoxalurie — Intestinale Oxalsäureresorption bei gastroenterologischen Erkrankungen. Klin Wochenschr 56:607

    PubMed  Google Scholar 

  8. Smith LH, Werness PG, Wilson DM (1979) Enteric hyperoxaluria and associated metabolic abnormalities that promote formation of renal calculi. In: Rose AG, Robertson WG, Watts RWE (eds) Oxalate in human biochemistry and clinical pathology. Wellcome Foundation Publications

  9. Tiselius HG, Ahlstrand C, Lundström B, Nilsson MA (1981)14C-Oxalate absorption by normal persons, calcium oxalate stone formers, and patients with surgically disturbed intestinal function. Clin Chem 27:1682

    PubMed  Google Scholar 

  10. Hanisch E, Scholz D, Schwille PO, Sörgel F, Sigel A (1982) Intestinale Absorption von14C-Oxalat bei Gesunden und Untergruppen der idiopathischen Calcium-Lithiasis. Fortschr Urol Nephrol 20:86

    Google Scholar 

  11. Pak CYC, Ohata N, Lawrence EC, Snyder (1974) The hypercalciurias: causes, parathyroid function, and diagnostic criteria. J Clin Invest 54:387

    PubMed  Google Scholar 

  12. Scholz D, Schwille PO, Engelhardt W, Morcinietz C (1979) Calcium metabolism following proximal gastric vagotomy in man. In: Norman AW, Schäfer K, v Herrath D, Grigoleit HG, Coburn JW, DeLuca HF, Mawer EB, Suda T (eds) Vitamin D, Basic Research and its Clinical Applications. De Gruyter, Berlin

    Google Scholar 

  13. Scholz D, Schwille PO, Bieger D, Schley HW, Zeuner E (1983) Intestinal calcium absorption and calcium metabolism, gastrin and calciotropic hormones before and after highly selective vagotomy for duodenal ulcer. Hepato-Gastroenterol (in press)

  14. Schwille PO, Mühe E, Gentsch H, Schellerer W, Scholz D (1980) Gastrinemia, serum minerals and calciotropic hormones following highly selective vagotomy in duodenal ulcer patients. Hepato-Gastroenterol 27:121

    Google Scholar 

  15. Kageyama N (1971) A direct colorimetric determination of uric acid in serum and urine with uricase-catalase system. Clin Chim Acta 31:421

    PubMed  Google Scholar 

  16. Moellering H, Gruber W (1966) Determination of citrate by citrate lyase. Anal Biochem 17:369

    PubMed  Google Scholar 

  17. Tschöpe W, Brenner R, Ritz E (1981) Isotachophoresis for the determination of oxalate in unprocessed urine. J Chromatogr 222:41

    PubMed  Google Scholar 

  18. Marshall RW, Robertson WG (1976) Nomograms for the estimation of the saturation of urine with calcium oxalate, calcium phosphate, magnesium, ammonium phosphate, uric acid, sodium acid urate, ammonium urate, and cystine. Clin Chim Acta 72:253

    PubMed  Google Scholar 

  19. Sachs L (1972) Statistiche Auswertungsmethoden. 3rd edn. Springer Berlin Heidelberg New York

    Google Scholar 

  20. Faxén A, Rossander L, Kewenter J (1979) The effect of parietal cell vagotomy and selective vagotomy with pyloroplasty on body weight and dietary habits. Scand J Gastroenterol 14:7

    PubMed  Google Scholar 

  21. Golematis B, Hatzitheofilou C, Dreiling DA, Kambysi-Dea S (1977) The incidence of urolithiasis in peptic ulcer patients. Am J Gastrenterol 68:367

    Google Scholar 

  22. Fleisch H (1978) Inhibitors and promoters of stone formation. Kid Int 13:361

    Google Scholar 

  23. Schwille PO, Scholz D, Schwille K, Leutschaft R, Goldberg I, Sigel A (1982) Citrate in urine, and serum and associated variables in subgroups of urolithiasis. Results from an out-patient stone clinic. Nephron 31:194

    PubMed  Google Scholar 

  24. Scholz D, Schwille PO, Sigel A (1981) Magnesiummangel bei Urolithiasis? Eine kritische Wiederbewertung. Fortschr Urol Nephrol 17:98

    Google Scholar 

  25. Hanisch E, Scholz D, Schwille PO, Sörgel F, Sigel A (1982) Intestinale Absorpion von14C-Citrat bei Gesunden und Untergruppen der idiopathischen Calcium-Lithiasis. Fortschr Urol Nephrol 20:452

    Google Scholar 

  26. Rotter JI (1980) The genetics of peptic ulcer: more than on gene, more than one disease. Progr Med Genet 4:1

    Google Scholar 

  27. Schwille PO, Mühe E, Gentsch H, Schellerer W, Scholz D (1980) Fasting blood values of glucose, insulin, glucagon, gastrin following highly selective vagotomy in duodenal ulcer patients. Eur Surg Res 12:159

    PubMed  Google Scholar 

  28. Berstad A, Roland M, Petersen H, Liavag J (1976) Altcred pancreatic function after proximal gastric vagotomy in man. Gastroenterology 71:958

    PubMed  Google Scholar 

  29. Lavigne ME, Zealous DW, Martin M, Way LW, Mayer JH, Sleisenger MH, McGregor JL (1979) Gastric, pancreatic and biliary secretion and the rate of gastric emptying after parietal cell vagotomy. Am J Surg 138:644

    PubMed  Google Scholar 

  30. Pak CYC, Eanes ED, Ruskin B (1971) Spontaneous precipitation of brushite in urine: evidence that brushite is the nidus of renal stones originating as calcium phosphate. Proc Natl Acad Sci USA 68:1456

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mineral Metabolism and Endocrine Research Laboratory, University of Erlangen, Germany

    P. O. Schwille MD, D. Scholz, E. Hanisch, E. Zeuner & H. Schwendtner

  2. Department of Surgery, University of Erlangen, Germany

    B. Husemann & E. Mühe

  3. Department Urology, University of Erlangen, Germany

    A. Sigel

Authors
  1. P. O. Schwille MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Scholz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Hanisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Zeuner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Schwendtner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Husemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Mühe
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Sigel
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Deutsche Forschungsgemeinschaft (Schw 210/3)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schwille, P.O., Scholz, D., Hanisch, E. et al. Urinary excretion of calcium, magnesium, oxalate and citrate in duodenal ulcer patients. preliminary results before and up to five years after highly selective vagotomy. Klin Wochenschr 61, 845–850 (1983). https://doi.org/10.1007/BF01537459

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01537459

Key words

Search

Navigation