CLINICAL EFFECT OF KETOTIFEN ON THE DEVELOPMENT OF ALLERGY MARCH Clinical Study Committee of Allergy March

Minoru Baba; Hirotaro Kawai; Takehiko Matsui; Tetsuo Kubagawa; Yoshiro Aoki; Shoichi Morota; Akinori Chiba; Aiko Mizuno; Shozaburo Suzuki; Ko Yoshitake; Ryoichi Watanabe; Chieko Tabata; Isamu Yamamoto; Yoshie Seki; Teruhiko Yamamoto; Takemaru Kikushima; Takehito Kuboshima; Kikuo Takahashi; Kimio Tatsuno; Katsumi Nakazawa; Kuniyoshi Iwatake; Zenzabro Shinma; Giichi Masuda; Soichiro Watanabe; Isamu Shibata; Kaoru Yamazaki

doi:10.3388/jspaci.2.41

Minoru Baba, Hirotaro Kawai, Takehiko Matsui, Tetsuo Kubagawa, Yoshiro Aoki, Shoichi Morota, Akinori Chiba, Aiko Mizuno, Shozaburo Suzuki, Ko Yoshitake, Ryoichi Watanabe, Chieko Tabata, Isamu Yamamoto, Yoshie Seki, Teruhiko Yamamoto, Takemaru Kikushima, Takehito Kuboshima, Kikuo Takahashi, Kimio Tatsuno, Katsumi Nakazawa, Kuniyoshi Iwatake, Zenzabro Shinma, Giichi Masuda, Soichiro Watanabe, Isamu Shibata, Kaoru Yamazaki

Author information

Minoru Baba
[in Japanese]
Hirotaro Kawai
[in Japanese]
Takehiko Matsui
[in Japanese]
Tetsuo Kubagawa
[in Japanese]
Yoshiro Aoki
[in Japanese]
Shoichi Morota
[in Japanese]
Akinori Chiba
[in Japanese]
Aiko Mizuno
[in Japanese]
Shozaburo Suzuki
[in Japanese]
Ko Yoshitake
[in Japanese]
Ryoichi Watanabe
[in Japanese]
Chieko Tabata
[in Japanese]
Isamu Yamamoto
[in Japanese]
Yoshie Seki
[in Japanese]
Teruhiko Yamamoto
[in Japanese]
Takemaru Kikushima
[in Japanese]
Takehito Kuboshima
[in Japanese]
Kikuo Takahashi
[in Japanese]
Kimio Tatsuno
[in Japanese]
Katsumi Nakazawa
[in Japanese]
Kuniyoshi Iwatake
[in Japanese]
Zenzabro Shinma
[in Japanese]
Giichi Masuda
[in Japanese]
Soichiro Watanabe
[in Japanese]
Isamu Shibata
[in Japanese]
Kaoru Yamazaki
[in Japanese]

Keywords: Allergy march, ketotifen

JOURNAL FREE ACCESS

1988 Volume 2 Issue 1 Pages 41-48

DOI https://doi.org/10.3388/jspaci.2.41

Details

Abstract

Children with atopic factors develop allergic diseases such as atopic dermatitis (AD), asthma (BA) and allergic rhinitis (AR) one after another (allergy march). Ketotifen was given to 124 children with allergic diseases aged 6 month to 15 years for 12 weeks in order to investigate the clinical efficacy of ketotifen on the progress of allergy march.
Symptoms were improved in 91.1% (i. e., markedly improved in 12.9%, moderatery improved in 47.6% and slightly improved in 30.6%), unchanged in 8.9%, and aggravated in 0%. Favorable results were obtained (p<0.001) from the attack score, severity of rhinitis and severity of AD of 58 cases of combined BA, AR, and AD, 32 of combined BA and AR and 34 of combined BA and AD. Further, sneezing and pruritus were alleviated significantly (p<0.05, p<0.001). These results suggest that ketotifen has a wide variety of pharmacological effects and can prevent the progress of allergy march.

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