A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis
Fig 4
The N-IF mouse liver phenotype can be transferred by hematopoietic cells.
(A) Liver weights of 10 week old N-IF mice, NOD.Rag2-/- mice and NOD.Rag2-/- mice adoptively transferred 5 weeks earlier with total spleen cells (NOD.Rag2-/- +total, n = 7) or total spleen cells depleted of NKT cells (NOD.Rag2-/- -NKT, n = 4) from 8–12 weeks old N-IF mice. Data are pooled from two independent experiments and shown as mean ± SEM. *** p<0.001by unpaired t-test. (B) Representative H&E stained liver sections from control NOD.Rag2-/- mice and adoptively transferred NOD.Rag2-/- mice receiving total spleen cells or total spleen cells depleted of transgenic NKT cells. Size bars are 100 μm.