Functional Real-Time Optoacoustic Imaging of Middle Cerebral Artery Occlusion in Mice
Figure 4
CBV ratio analysis for all the 7 imaged animals based on single wavelength optoacoustic images acquired at isosbestic wavelength of blood at 790 nm.
Ratios of the mean in the ischemic cortex to the mean of its contralateral counterpart were calculated for the cortical areas (marked by red squares in Figs. 2A and 2C) and striatum areas (marked by green squares in Figs. 2A and 2C) and % changes relative to pre-ischemia values are presented. A: All mice show reduction in CBV in the cortex, followed by return to normal values after reperfusion at 24 h (middle). B: For the striatum areas, the mice show an increase of CBV during ischemia, which remains elevated in most of the animals after reperfusion. Averaged data of absolute ratio values from all the mice (box plots with median and 25th and 75th percentile) are shown in panels C and D for the cortical and striatum areas, respectively.