Genetic Basis of Virulence Attenuation Revealed by Comparative Genomic Analysis of Mycobacterium tuberculosis Strain H37Ra versus H37Rv
Figure 1
Atlas of the Chromosome of M. tuberculosis H37Ra ATCC25177 and its Comparison with M. tuberculosis H37Rv.
Moving inside, each concentric circle represents genomic data for M. tuberculosis H37Ra and its comparison with M. tuberculosis H37Rv. The outer circle illustrates predicted coding sequences on the plus and minus strands, respectively, colored by functional categories according to COG classification. The 2nd circle represents location of nucleotide substitution in coding regions (purple for synonymous substitutions; green for nonsynonymous substitutions) and noncoding regions (red), respectively. The 3rd circle displays loci of insertions in H37Ra, distinguished by coding regions (red) and noncoding regions (purple). The 4th circle shows loci of deletions in H37Ra, distinguished by coding regions (red) and noncoding regions (purple). The 5th circle presents H37Ra specific genes compared with H37Rv and CDC151 genes, red for CDSs with variations and green for genes with promoter variations. The 6th circle (innermost) represents GC skew (G−C)/(G+C) calculated using a 5 kb window.