Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile
Fig 1
Multiple polypeptide alignment of CsSBAT and bile acid transporters from other species.
Sequences were aligned and calculated using MAFFT v7.299 [35] with manual adjustment in Jalview [36]. Residues over 50% conserved among the transporters are shaded in light blue and 100% conserved residues are highlighted in dark blue. Residues that interact with sodium ions are labeled: Na1 site (●), Na2 site (■), and putative Na3 site (★). Residues necessary to coordinate with taurocholate in CsSBAT are also indicated (▲). Bile acid transporters are Opisthorchis viverrini SBAT (OvSBAT; A0A074Z5N1), Paragonimus westermani SBAT (PwSBAT; A0A5J4NIG5), Echinococcus granulosus SBAT (EgSBAT; W6UF08), human ASBT (HsASBT; Q12908), human NTCP (HsNTCP; Q14973), Neisseria meningitidis ASBT (NmASBT; Q9K0A9), and Yersinia frederiksenii ASBT (YfASBT; C4ST46).