Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome
Fig 5
Receiver Operating Characteristic (ROC) curves and Areas Under the ROC Curves (AUC).
(A) Cross-validation performance of MutPred-Indel with per-protein and per-cluster training, as well as the performance of a model with training data that includes singleton variants in gnomAD. (B) Cross-validation performance of MutPred-Indel on insertions, deletions, and complex indel variants separately. (C) Performance of MutPred-Indel and MutPred2 on single amino acid insertion/deletion variants. (D) Comparison of MutPred-Indel and three existing methods.