Abstract
Three bovine serum albumin-specific Lyt-2+ T suppressor (Ts) cell clones from CBA/J mice have been analyzed with regard to expression of L3T4 molecules. All three Ts-cell clones can be stained with monoclonal antibodies (mAb) to L3T4. Tested for the two clones restricted to recognition of Ek determinants, antigen-specific proliferation on antigen-presenting cells, but not the proliferation induced by conditioned medium can be inhibited by L314-specific mAb. In a similar way, Ts-cell cytolytic effector functions can be blocked by L3T4-specific mAb. Thus L3T4 structures seem to play a role in Ts-cell functions. Furthermore, the data support the view that L3T4 expression can be a property of class II-restricted T cells irrespective of their Lyt phenotype.
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Heuer, J., Degwert, J. & Kölsch, E. Expression of L3T4 molecules on Lyt-2+, class II-restricted antigen-specific T suppressor lymphocytes. Immunogenetics 24, 316–323 (1986). https://doi.org/10.1007/BF00395537
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DOI: https://doi.org/10.1007/BF00395537