Summary
We have confirmed that doxorubicin induces irreversible changes in the nucleolar ultrastructure of myocardial cells of rats. Similar changes were not caused by an equal dose of the synthetic analogue, 5-iminodaunomycin. These results combined with previous and current comparative tests with this analogue, doxorubicin, and daunomycin suggest that 5-iminodaunomycin may serve as a less cardiotoxic anthracycline derivative.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bachur NR, Gordon SL, Gee MV, Kon H (1979) NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci USA 76:954
Blum RH, Carter SK (1974) Adriamycin. A new anticancer drug with significant clinical activity. Ann Intern Med 80:249
Carter SK (1975) Adriamycin — a review. J Natl Cancer Inst 55:1265
Goodman J, Hochstein P (1977) Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunorubicin. Biochem Biophys Res Commun 77:797
Gordon GR, Peters JH, Acton EM (1980) Augmentation of microsomal oxygen consumption by anthracyclines and related phenazines. Abstracts of the Annual Meetings of the American Chemical Society, August 24–29, Las Vegas, NV (Abstract No. 136)
Lambertenghi-Deliliers G, Zanon PL, Pozzoli EF, Bellini O (1976) Myocardial injury induced by a single dose of adriamycin: an electron microscopic study. Tumori 62:517
Lown JW, Chen H, Plambeck JA, Acton EM (1979) Diminished superoxide anion generation by reduced 5-iminodaunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents. Biochem Pharmacol 28:2563
Merski JA, Daskal Y, Busch H (1976) Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat. Cancer Res 36:1580
Merski JA, Daskal Y, Crooke ST, Busch H (1979) Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues. Cancer Res 39:1239
Tong GL, Henry DW, Acton EM (1979) 5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline. J Med Chem 22:36
Zbinden G, Backmann E, Holderegger C (1978) Model systems for cardiotoxic effects of anthracyclines. Antibiot Chemother 23:255
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peters, J.H., Evans, M.J., Jensen, R.A. et al. Effects of 5-iminodaunorubicin on nucleoli of rats. Cancer Chemother. Pharmacol. 4, 263–266 (1980). https://doi.org/10.1007/BF00255271
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00255271