Summary
A 34-year-old white man with generalized neurofibromatosis was found to have severe renal vascular hypertension due to a coarctation of the abdominal aorta and bilateral renal artery stenosis with saccular aneurysms. Increased renal venous renin activity showed the active involvement of the renin-angiotensin system in maintaining the hypertension. Because the patient refused surgical treatment, antihypertensive treatment with Captopril, a specific inhibitor of the angiotensin converting enzyme was used, resulting in normal blood pressure being restored over an 18 month observation period.
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Abbreviations
- ACE:
-
angiotensin converting enzyme
References
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Herrn Prof. Dr. med. H. Losse zum 65. Geburtstag gewidmet
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Tenschert, W., Holdener, E.E., Haertel, M.M. et al. Secondary hypertension and neurofibromatosis: Bilateral renal artery stenosis and coarctation of the abdominal aorta. Klin Wochenschr 63, 593–596 (1985). https://doi.org/10.1007/BF01733011
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DOI: https://doi.org/10.1007/BF01733011