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Intravoxel incoherent motion (IVIM) at 3.0 T: evaluation of early renal function changes in type 2 diabetic patients

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Abstract

Purpose

The purpose of this study was to evaluate the utility of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) parameters in identifying early renal function changes in diabetics.

Methods

A total of 40 patients with type 2 diabetes mellitus and 20 healthy control subjects underwent multiple b value DWI. The diabetic patients were stratified into two groups based on albuminuria category: NAU (normal to mildly increased albuminuria; ACR < 30 mg/g) and MAU (moderately increased albuminuria; 30 ≤ ACR < 300 mg/g). The mean cortical and medullary IVIM parameters (D, D*, f, and ADC) were calculated and compared among the different groups, and the correlation of ACR and eGFR was also calculated.

Results

The present study revealed the limited water molecule diffusion and hyperperfusion of renal cortex and medulla in diabetic patients before proteinuria detection. Mean cortical and medullary D values negatively correlated with the ACR values in diabetics with 30 ≤ ACR < 300 mg/g, whereas no correlation was found between ACR values and other IVIM parameters.

Conclusion

IVIM DWI might be helpful in noninvasively identifying early-stage DN. The IVIM parametric values are more sensitive than the ACR in detecting early-stage kidney changes.

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Acknowledgments

The authors wish to thank Zhong-Ping Zhang, advanced application specialist at GE Healthcare MR research China, Guangzhou, for his technical consultation for practicing the IVIM protocol.

Author information

Author notes

  1. You-Zhen Feng and Xiao-Qiao Chen contributed equally to this study.

Authors and Affiliations

  1. Medical Imaging Center, First Affiliated Hospital, Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, 510630, China

    You-Zhen Feng, Xiao-Qiao Chen, Xiao-Ling Liu, Zhong-Yuan Cheng & Xiang-Ran Cai

  2. Department of Medical Imaging, Shenzhen Second People’s Hospital, Shenzhen University, Shenzhen, Guangdong, China

    Juan Yu

  3. Endocrinology Department, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China

    Wei-Wei Ren & Lie Feng

Authors
  1. You-Zhen Feng
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  2. Xiao-Qiao Chen
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  7. Lie Feng
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Corresponding author

Correspondence to Xiang-Ran Cai.

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Funding

This study was supported by the Guangdong Science and Technology project in China (Grant No. 2014A020212442).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Feng, YZ., Chen, XQ., Yu, J. et al. Intravoxel incoherent motion (IVIM) at 3.0 T: evaluation of early renal function changes in type 2 diabetic patients. Abdom Radiol 43, 2764–2773 (2018). https://doi.org/10.1007/s00261-018-1555-7

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  • DOI: https://doi.org/10.1007/s00261-018-1555-7

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