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Das Mikrobiom des infizierten Magens und Duodenums

Helicobacter pylori und andere Bakterien

The microbiome of the infected stomach and duodenum

Helicobacter pylori and other bacteria Redaktion

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Der Gastroenterologe Aims and scope

Zusammenfassung

Wurde durch die Entdeckung von Helicobacter plyori das Konzept des sterilen Magens ein erstes Mal revidiert, muss durch die Anwendung molekularbiologischer Verfahren und die Ergebnisse tierexperimenteller Arbeiten auch der Einfluss anderer Bakterien auf Erkrankungen des Magens und des Duodenums angenommen werden. Unverändert ist die Unterscheidung zwischen transienten und residenten Bakterien und ihre detaillierte Rolle im Zusammenspiel der gesamten mikrobiellen Gemeinschaft nicht in allen Einzelheiten verstanden. Dieser Review vermittelt einen Überblick zum derzeitigen Kenntnisstand über Helicobacter pylori und andere Bakterien des oberen Gastrointestinaltrakts in Zusammenhang mit gastroduodenalen Erkrankungen.

Abstract

With the discovery of Helicobacter pylori, the concept of the stomach being a sterile organ changed for the first time. The use of modern nucleotide sequencing and culture-independent techniques as well as animal studies suggest an influence of bacteria other than Helicobacter plyori on gastroduodenal pathologies. The differentiation of resident and transient bacteria and the understanding of their detailed functions inside of the bacterial community remain unclear. This review provides a concise overview on the current knowledge of Helicobacter pylori and other bacteria in the relationship with gastroduodenal pathologies.

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Literatur

  1. Aebischer T, Bumann D, Epple H‑J et al (2008) Correlation of T cell response and bacterial clearance in human volunteers challenged with helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines. Gut 57:1065–1072

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Anonymous (1989) Campylobacter pylori becomes helicobacter pylori. Lancet 2:1019–1020

    Google Scholar 

  3. Anonymous (2016) S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit. Z Gastroenterol 54:327–363

    Article  Google Scholar 

  4. Atherton JC, Cao P, Peek RM et al (1995) Mosaicism in vacuolating cytotoxin alleles of helicobacter pylori association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270:17771–17777

    Article  CAS  PubMed  Google Scholar 

  5. Bassis CM, Erb-Downward JR, Dickson RP et al (2015) Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. MBio 6:e00037–15

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bauerfeind P, Garner R, Dunn B et al (1997) Synthesis and activity of helicobacter pylori urease and catalase at low pH. Gut 40:25–30

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bizzozero G (1893) Sulle ghiandole tubulari del tubo gastroenterico e sui rapporti del loro coll’epitelio di rivestimento della mucosa. Arch Mikr Anat 42:82

    Article  Google Scholar 

  8. De Witte C, Schulz C, Smet A et al (2016) Other helicobacters and gastric microbiota. Helicobacter 21(Suppl 1):62–68

    Article  PubMed  Google Scholar 

  9. Figueiredo C, Machado JC, Pharoah P et al (2002) Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 94:1680–1687

    Article  CAS  PubMed  Google Scholar 

  10. Franck C, Hoffmann A, Link A et al (2017) Prevalence of helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany—a region at intermediate risk for gastric cancer. Z Gastroenterol 55(7):653–656. https://doi.org/10.1055/s-0043-106311

    Article  PubMed  Google Scholar 

  11. Goh KL, Chan WK, Shiota S et al (2011) Epidemiology of helicobacter pylori infection and public health implications. Helicobacter 16:1–9

    Article  PubMed  PubMed Central  Google Scholar 

  12. González CA, Figueiredo C, Lic CB et al (2011) Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: a long-term follow-up in a high-risk area in Spain. Am J Gastroenterol 106:867–874

    Article  PubMed  Google Scholar 

  13. Graham D, Opekun A, Osato M et al (2004) Challenge model for helicobacter pylori infection in human volunteers. Gut 53:1235–1243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Krienitz W (1906) Ueber das Auftreten von Spirochäten verschiedener Form im Mageninhalt bei Carcinoma ventriculi. Dtsch Med Wochenschr 32:872–872

    Article  Google Scholar 

  15. Lertpiriyapong K, Whary MT, Muthupalani S et al (2013) Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis. Gut 63(1):54–63. https://doi.org/10.1136/gutjnl-2013-305178

    Article  PubMed  PubMed Central  Google Scholar 

  16. Li G, Yang M, Zhou K et al (2015) Diversity of duodenal and rectal microbiota in biopsy tissues and luminal contents in healthy volunteers. J Microbiol Biotechnol 25:1136–1145

    Article  CAS  PubMed  Google Scholar 

  17. Linz B, Balloux F, Moodley Y et al (2007) An African origin for the intimate association between humans and helicobacter pylori. Nature 445:915–918

    Article  PubMed  PubMed Central  Google Scholar 

  18. Liu J, He C, Chen M et al (2013) Association of presence/absence and on/off patterns of helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis. BMC Infect Dis 13:555

    Article  PubMed  PubMed Central  Google Scholar 

  19. Lu H, Hsu P‑I, Graham DY et al (2005) Duodenal ulcer promoting gene of helicobacter pylori. Gastroenterology 128:833–848

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Maixner F, Krause-Kyora B, Turaev D et al (2016) The 5300-year-old helicobacter pylori genome of the Iceman. Science 351:162–165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Malfertheiner P, Bazzoli F, Delchier J (2011) Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial (vol 377, pg 905, 2011). Lancet 378:1778–1778

    Article  Google Scholar 

  22. Malfertheiner P, Megraud F, O’morain CA et al (2017) Management of helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 66:6–30

    Article  CAS  PubMed  Google Scholar 

  23. Mayerle J, Den Hoed CM, Schurmann C et al (2013) Identification of genetic loci associated with helicobacter pylori serologic status. JAMA 309:1912–1920

    Article  CAS  PubMed  Google Scholar 

  24. Moodley Y, Linz B, Bond RP et al (2012) Age of the association between helicobacter pylori and man. PLoS Pathog 8:e1002693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Moran C, Sheehan D, Shanahan F (2015) The small bowel microbiota. Curr Opin Gastroenterol 31:130–136

    Article  CAS  PubMed  Google Scholar 

  26. Moreno Y, Ferrus M, Alonso J et al (2003) Use of fluorescent in situ hybridization to evidence the presence of helicobacter pylori in water. Water Res 37:2251–2256

    Article  CAS  PubMed  Google Scholar 

  27. Pimentel M, Chow EJ, Lin HC (2000) Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95:3503–3506

    Article  CAS  PubMed  Google Scholar 

  28. Sanduleanu S, Jonkers D, De Bruine A et al (2001) Non-Helicobacter pylori bacterial flora during acid-suppressive therapy: differential findings in gastric juice and gastric mucosa. Aliment Pharmacol Ther 15:379–388

    Article  CAS  PubMed  Google Scholar 

  29. Schulz C, Koch N, Schütte K et al (2015) H. pylori and its modulation of gastrointestinal microbiota. J Dig Dis 16:109–117

    Article  PubMed  Google Scholar 

  30. Schulz C, Schütte K, Koch N et al (2016) The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection. Gut 67(2):216–225. https://doi.org/10.1136/gutjnl-2016-312904

    Article  PubMed  Google Scholar 

  31. Schulz C, Schütte K, Kropf S et al (2016) RiMINI – the influence of rifaximin on minimal hepatic encephalopathy (MHE) and on the intestinal microbiome in patients with liver cirrhosis: study protocol for a randomized controlled trial. Trials 17:111

    Article  PubMed  PubMed Central  Google Scholar 

  32. Schulz CS, Schütte K, Reisener N, Voss J, Kandulski A, Malfertheiner P (2016) Small intestinal bacterial overgrowth is not associated with minimal hepatic encephalopathy in patients with liver cirrhosis. J Gastroenerol Hepatol Endosc 1(1):1–4

    Google Scholar 

  33. Scott DR, Marcus EA, Weeks DL et al (2002) Mechanisms of acid resistance due to the urease system of helicobacter pylori. Gastroenterology 123:187–195

    Article  CAS  PubMed  Google Scholar 

  34. Sugano K, Tack J, Kuipers EJ et al (2015) Kyoto global consensus report on helicobacter pylori gastritis. Gut 64:1353–1367

    Article  PubMed  PubMed Central  Google Scholar 

  35. Tsuda A, Suda W, Morita H et al (2015) Influence of proton-pump inhibitors on the luminal microbiota in the gastrointestinal tract. Clin Transl Gastroenterol 6:e89

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Vale F, Vítor J (2010) Transmission pathway of helicobacter pylori: does food play a role in rural and urban areas? Int J Food Microbiol 138:1–12

    Article  CAS  PubMed  Google Scholar 

  37. Velázquez M, Feirtag JM (1999) Helicobacter pylori: characteristics, pathogenicity, detection methods and mode of transmission implicating foods and water. Int J Food Microbiol 53:95–104

    Article  PubMed  Google Scholar 

  38. Wang Z‑K, Yang Y‑S (2013) Upper gastrointestinal microbiota and digestive diseases. World J Gastroenterol 19:1541

    Article  PubMed  PubMed Central  Google Scholar 

  39. Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273–1275

    CAS  PubMed  Google Scholar 

  40. Wex T, Venerito M, Kreutzer J et al (2011) Serological prevalence of helicobacter pylori infection in Saxony-Anhalt, Germany, in 2010. Clin Vaccine Immunol 18:2109–2112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Yamaoka Y (2010) Virulence factors of helicobacter pylori: up-to-date. Nihon Shokakibyo Gakkai Zasshi 107:1262–1272

    PubMed  Google Scholar 

  42. Yamaoka Y, Kodama T, Gutierrez O et al (1999) Relationship between helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J Clin Microbiol 37:2274–2279

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Yamaoka Y, Ojo O, Fujimoto S et al (2006) Helicobacter pylori outer membrane proteins and gastroduodenal disease. Gut 55:775–781

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Yamaoka Y, Souchek J, Odenbreit S et al (2002) Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of helicobacter pylori. J Clin Microbiol 40:2244–2246

    Article  PubMed  PubMed Central  Google Scholar 

  45. Zilberstein B, Quintanilha AG, Santos MA et al (2007) Digestive tract microbiota in healthy volunteers. Clinics 62:47–54

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik 2, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland

    C. Schulz, L. Macke, P. Malfertheiner & J. Mayerle

  2. Klinik für Innere Medizin A, Universitätsmedizin Greifswald, Greifswald, Deutschland

    F. Frost

  3. Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Fakultät, LMU München, München, Deutschland

    S. Suerbaum

  4. Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Magdeburg, Magdeburg, Deutschland

    P. Malfertheiner

Authors
  1. C. Schulz
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  2. L. Macke
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  4. S. Suerbaum
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  5. P. Malfertheiner
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  6. J. Mayerle
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Correspondence to C. Schulz.

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Interessenkonflikt

C. Schulz, L. Macke, F. Frost, S. Suerbaum, P. Malfertheiner und J. Mayerle geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Redaktion

M. Ebert, Mannheim

M. Müller-Schilling, Regensburg

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Schulz, C., Macke, L., Frost, F. et al. Das Mikrobiom des infizierten Magens und Duodenums. Gastroenterologe 13, 106–112 (2018). https://doi.org/10.1007/s11377-018-0233-1

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