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Evidenzbasiertes endoskopisches Management des Barrett-Ösophagus

Evidence-based endoscopic management of Barrett’s esophagus

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Der Gastroenterologe Aims and scope

Zusammenfassung

Hintergrund

Neue Studiendaten zum Barrett-Ösophagus haben bisherige Überwachungsstrategien und Empfehlungen infrage gestellt. Die Fachgesellschaften haben daher ihre Leitlinien überarbeitet.

Ziel der Arbeit

Die vorliegende Arbeit widmet sich dem diagnostischen und therapeutischen Vorgehen bei Barrett-Ösophagus, basierend auf den aktuellen Empfehlungen der DGVS.

Material und Methoden

Literaturrecherche zum Thema Barrett-Ösophagus. Die für das endoskopische Management wesentlichen Aspekte werden dargestellt und diskutiert.

Fazit

Es liegen neue Erkenntnisse zu Karzinominzidenz und Progressionsrisiko vor, zum Stellenwert von leichtgradigen intraepithelialen Neoplasien (LGIN) und der Effektivität unterschiedlicher endoskopischer Therapiemöglichkeiten. Diese fanden Eingang in die Empfehlungen der neuen DGVS-Leitlinie.

Abstract

Background

Former recommendations concerning the endoscopic management of Barrett’s esophagus have been questioned by recent studies. Medical societies have therefore implemented new guidelines.

Objectives

This review article discusses the diagnostic and therapeutic strategies in patients with Barrett’s esophagus based on the new guidelines of the German Society of Gastroenterology (DGVS).

Methods

A literature search was carried out for reports associated with this topic. Aspects relevant to the endoscopic management of Barrett’s esophagus are described and discussed.

Conclusion

New findings on the cancer risk, the role of low grade dysplasia and on endoscopic therapy options have been integrated into the new guideline recommendations.

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Literatur

  1. Anaparthy R, Gaddam S, Kanakadandi V et al (2013) Association between length of Barrett’s esophagus and risk of high-grade dysplasia or adenocarcinoma in patients without dysplasia. Clin Gastroenterol Hepatol 11: 1430–1436

    Article  PubMed  Google Scholar 

  2. Bhat S, Coleman HG, Yousef F et al (2011) Risk of malignant progression in Barrett’s esophagus patients: results from a large population-based study. J Natl Cancer Inst 103: 1049–1057

    Article  PubMed Central  PubMed  Google Scholar 

  3. Chak A, Faulx A, Eng C et al (2006) Gastroesophageal reflux symptoms in patients with adenocarcinoma of the esophagus or cardia. Cancer 107: 2160–2166

    Article  PubMed  Google Scholar 

  4. Curvers WL, Kate FJ ten, Krishnadath KK et al (2010) Low-grade dysplasia in Barrett’s esophagus: overdiagnosed and underestimated. Am J Gastroenterol 105: 1523–1530

    Article  PubMed  Google Scholar 

  5. Desai TK, Krishnan K, Samala N et al (2012) The incidence of oesophageal adenocarcinoma in non-dysplastic Barrett’s oesophagus: a meta-analysis. Gut 61: 970–976

    Article  PubMed  Google Scholar 

  6. Gaddam S, Singh M, Balasubramanian G et al (2013) Persistence of nondysplastic Barrett’s esophagus identifies patients at lower risk for esophageal adenocarcinoma: results from a large multicenter cohort. Gastroenterology 145: 548–553.e1

    Article  PubMed  Google Scholar 

  7. Gatenby PAC, Ramus JR, Caygill CPJ et al (2008) Relevance of the detection of intestinal metaplasia in non-dysplastic columnar-lined oesophagus. Scand J Gastroenterol 43: 524–530

    Article  PubMed  Google Scholar 

  8. Gupta M, Iyer PG, Lutzke L et al (2013) Recurrence of esophageal intestinal metaplasia after endoscopic mucosal resection and radiofrequency ablation of Barrett’s esophagus: results from a US multicenter consortium. Gastroenterology 145: 79–86.e1

    Article  PubMed Central  PubMed  Google Scholar 

  9. Höbel S, Dautel P, Baumbach R et al (2014) Single center experience of endoscopic submucosal dissection (ESD) in early Barrett’s adenocarcinoma. Surg Endosc

  10. Hvid-Jensen F, Pedersen L, Drewes AM et al (2011) Incidence of Adenocarcinoma among patients with Barrett’s Esophagus. N Engl J Med 365: 1375–1383

    Article  CAS  PubMed  Google Scholar 

  11. Kelty CJ, Gough MD, Van Wyk Q et al (2007) Barrett’s oesophagus: intestinal metaplasia is not essential for cancer risk. Scand J Gastroenterol 42: 1271–1274

    Article  PubMed  Google Scholar 

  12. Koop H, Fuchs K-H, Labenz J et al (2014) S2k-Leitlinie Gastroösophageale Refluxkrankkheit (AWMF Register Nr. 021/013) unter Federführung Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). http://www.awmf.org/uploads/tx_szleitlinien/021-013l_S2k_Refluxkrankheit_2014-05.pdf

  13. Mannath J, Subramanian V, Hawkey CJ, Ragunath K (2010) Narrow band imaging for characterization of high grade dysplasia and specialized intestinal metaplasia in Barrett’s esophagus: a meta-analysis. Endoscopy 42: 351–359

    Article  CAS  PubMed  Google Scholar 

  14. Orman ES, Li N, Shaheen NJ (2013) Efficacy and durability of radiofrequency ablation for Barrett’s esophagus: systematic review and meta-analysis. Clin Gastroenterol Hepatol 11: 1245–1255

    Article  PubMed  Google Scholar 

  15. Pech O, Behrens A, May A et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57: 1200–1206

    Article  CAS  PubMed  Google Scholar 

  16. Pech O, Gossner L, Manner H et al (2007) Prospective evaluation of the macroscopic types and location of early Barrett’s neoplasia in 380 lesions. Endoscopy 39: 588–593

    Article  CAS  PubMed  Google Scholar 

  17. Pech O, May A, Manner H et al (2014) Long-term efficacy and safety of endoscopic resection for patients with mucosal adenocarcinoma of the esophagus. Gastroenterology 146: 652–660.e1

    Article  PubMed  Google Scholar 

  18. Pohl H, Sirovich B, Welch HG (2010) Esophageal adenocarcinoma incidence: are we reaching the peak? Cancer Epidemiol Biomarkers Prev 19: 1468–1470

    Article  PubMed  Google Scholar 

  19. Probst A, Aust D, Märkl B et al (2014) Early esophageal cancer in Europe- endoscopic treatment by endoscopic submucosal dissection. Endoscopy (in press)

  20. Rastogi A, Puli S, El-Serag HB et al (2008) Incidence of esophageal adenocarcinoma in patients with Barrett’s esophagus and high-grade dysplasia: a meta-analysis. Gastrointest Endosc 67: 394–398

    Article  PubMed  Google Scholar 

  21. Rex DK, Cummings OW, Shaw M et al (2003) Screening for Barret’s esophagus in colonoscopy patients with and without heartburn. Gastroenterology 125: 1670–1677

    Article  PubMed  Google Scholar 

  22. Shaheen NJ, Sharma P, Overholt BF et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med 360: 2277–2288

    Article  CAS  PubMed  Google Scholar 

  23. Sharma P, Dent J, Armstrong D et al (2006) The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria. Gastroenterology 131: 1392–1399

    Article  PubMed  Google Scholar 

  24. Spechler SJ, Souza RF (2014) Barret’s esophagus. N Engl J Med 371: 836–845

    Article  CAS  PubMed  Google Scholar 

  25. Takubo K, Aida J, Naomoto Y et al (2009) Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum Pathol 40: 65–74

    Article  PubMed  Google Scholar 

  26. Van Vilsteren FGI, Pouw RE, Herrero LA et al (2012) Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program. Endoscopy 44: 4–12

    Article  Google Scholar 

  27. Westerhoff M, Hovan L, Lee C, Hart J (2012) Effects of dropping the requirement for goblet cells from the diagnosis of Barrett’s esophagus. Clin Gastroenterol Hepatol 10: 1232–1236

    Article  PubMed  Google Scholar 

  28. Wright TA (1997) High-grade dysplasia in Barrett’s oesophagus. Br J Surg 84: 760–766

    Article  CAS  PubMed  Google Scholar 

  29. Zemler B, May A, Ell C, Stolte M (2010) Early Barrett’s carcinoma: the depth of infiltration of the tumour correlates with the degree of differentiation, the incidence of lymphatic vessel and venous invasion. Virchows Arch Int J Pathol 456: 609–614

    Article  Google Scholar 

  30. Krebs in Deutschland 2009/2010. https: //www.gbe-bund.de/gbe10/owards.prc. Zugriff: 30. Sept. 2014

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Einhaltung der ethischen Richtlinien

Interessenskonflikt. D. Golger, A. Probst und H. Messmann geben an, dass kein Interessenskonflikt besteht. Dieser Beitragt beinhaltet keine Studien an Menschen oder Tieren.

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Correspondence to H. Messmann.

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Golger, D., Probst, A. & Messmann, H. Evidenzbasiertes endoskopisches Management des Barrett-Ösophagus. Gastroenterologe 10, 7–16 (2015). https://doi.org/10.1007/s11377-014-0936-x

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  • DOI: https://doi.org/10.1007/s11377-014-0936-x

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