“Rejoice, Texandria, for Oda!” Thus begins the series of chants and readings commemorating the virgin St Oda, patron of the village that took her name—Sint-Oedenrode—in the late medieval liturgy of the town of ’s-Hertogenbosch. Overt praise for the surrounding region, Texandria, extending across the northern limits of the duchy of Brabant and diocese of Liège, is a recurring theme in the liturgy inspired by the saint’s legend. Yet how did Oda, of Scottish origin, become so closely associated with this remote region? And what was the significance of her liturgical veneration in ’s-Hertogenbosch, to which Sint-Oedenrode was enfranchised? Exemplifying interactions between central and secondary places within a specific region, this study argues for the relevance of the historical approach to urban–rural dynamics in medieval hagiography and its related liturgy. Recognition that smaller towns and villages played important roles in regional networks prompts more focused attention to regional priorities in the legends and liturgies of local saints. That Oda’s cult is attested by a diversity of extant documentary evidence—historical, hagiographic, and liturgical, including newly discovered liturgical readings—facilitates interpretation of her veneration in ’s-Hertogenbosch and of the intertextual connections between her legend and those of other saints, notably Lambert, associated with the duchy and diocese. As suggested by this example, regionalism merits greater scrutiny as an integral component of civic religion. Full article

Pathogenic variants in the FAN1 gene lead to a systemic disease with karyomegalic interstitial nephritis (KIN) at the forefront clinically. The phenotypic–genotypic features of a FAN1 mutation-related disease involving five members of a Hungarian Caucasian family are presented. Each had adult-onset chronic kidney disease of unknown cause treated with renal replacement therapy and elevated liver enzymes. Short stature, emaciation, latte-colored skin, freckles, and a hawk-like nose in four patients, a limited intellect in two patients, and chronic restrictive lung disease in one patient completed the phenotype. Severe infections occurred in four patients. All five patients had ceased. Four patients underwent autopsy. KIN and extrarenal karyomegaly were observed histologically; the livers showed no specific abnormality. The genotyping using formalin-fixed tissue samples detected a hitherto undescribed homozygous FAN1 mutation (c.1673_1674insT/p.Met558lfs*4; exon 5) in three of these patients and a heterozygous FAN1 mutation in one patient. The reason for the heterozygosity is discussed. In addition, 56 family members consented to the screening for FAN1 mutation from which 17 individuals proved to be heterozygous carriers; a blood chemistry evaluation of their kidney and liver function did not find any abnormality. The clinical presentation of FAN1-related disease was multifaceted, and not yet described manifestations were observed besides kidney and liver disease. Mutation in this gene should be suspected in adults with small kidneys of unknown cause, elevated liver enzymes, and recurrent infections, even without a family history. Full article

In this paper, we present the exploration of indoor positioning technologies for UAVs, as well as navigation techniques for path planning and obstacle avoidance. The objective was to perform warehouse inventory tasks, using a drone to search for barcodes or markers to identify objects. For the indoor positioning techniques, we employed visual-inertial odometry (VIO), ultra-wideband (UWB), AprilTag fiducial markers, and simultaneous localization and mapping (SLAM). These algorithms included global positioning, local positioning, and pre-mapping positioning, comparing the merits and drawbacks of various techniques and trajectories. For UAV navigation, we combined the SLAM-based RTAB-map indoor mapping and navigation path planning of the ROS for indoor environments. This system enabled precise drone positioning indoors and utilized global and local path planners to generate flight paths that avoided dynamic, static, unknown, and known obstacles, demonstrating high practicality and feasibility. To achieve warehouse inventory inspection, a reinforcement learning approach was proposed, recognizing markers by adjusting the UAV’s viewpoint. We addressed several of the main problems in inventory management, including efficiently planning of paths, while ensuring a certain detection rate. Two reinforcement learning techniques, AC (actor–critic) and PPO (proximal policy optimization), were implemented based on AprilTag identification. Testing was performed in both simulated and real-world environments, and the effectiveness of the proposed method was validated. Full article

Agricultural insects play a crucial role in transmitting plant viruses and host a considerable number of insect-specific viruses (ISVs). Among these insects, the white-backed planthoppers (WBPH; Sogatella furcifera, Hemiptera: Delphacidae) are noteworthy rice pests and are responsible for disseminating the southern rice black-streaked dwarf virus (SRBSDV), a significant rice virus. In this study, we analyzed WBPH transcriptome data from public sources and identified three novel viruses. These newly discovered viruses belong to the plant-associated viral family Solemoviridae and were tentatively named Sogatella furcifera solemo-like virus 1-3 (SFSolV1-3). Among them, SFSolV1 exhibited a prevalent existence in different laboratory populations, and its complete genome sequence was obtained using rapid amplification of cDNA ends (RACE) approaches. To investigate the antiviral RNA interference (RNAi) response in WBPH, we conducted an analysis of virus-derived small interfering RNAs (vsiRNAs). The vsiRNAs of SFSolV1 and -2 exhibited typical patterns associated with the host’s siRNA-mediated antiviral immunity, with a preference for 21- and 22-nt vsiRNAs derived equally from both the sense and antisense genomic strands. Furthermore, we examined SFSolV1 infection and distribution in WBPH, revealing a significantly higher viral load of SFSolV1 in nymphs’ hemolymph compared to other tissues. Additionally, in adult insects, SFSolV1 exhibited higher abundance in male adults than in female adults. Full article

As solid organ transplant (SOT) recipients remain at risk of severe outcomes after SARS-CoV-2 infections, vaccination continues to be an important preventive measure. In SOT recipients previously vaccinated with at least three doses of BNT162b2, we investigated humoral responses to BNT162b2 booster doses. Anti-SARS-CoV-2 receptor binding domain (RBD) immunoglobulin G (IgG) was measured using an in-house ELISA. Linear mixed models were fitted to investigate the change in the geometric mean concentration (GMC) of anti-SARS-CoV-2 RBD IgG after vaccination in participants with intervals of more or less than six months between the last two doses of vaccine. We included 107 SOT recipients vaccinated with a BNT162b2 vaccine. In participants with an interval of more than six months between the last two vaccine doses, we found a 1.34-fold change in GMC per month (95% CI 1.25–1.44), while we found a 1.09-fold change in GMC per month (95% CI 0.89–1.34) in participants with an interval of less than six months between the last two vaccine doses, resulting in a rate ratio of 0.82 (95% CI 0.66 to 1.01, p = 0.063). In conclusion, the administration of identical COVID-19 mRNA vaccine boosters within six months to SOT recipients may result in limited humoral immunogenicity of the last dose. Full article

As a project construction organization model, whole-process engineering consulting (WPEC) is currently being promoted in China’s engineering consulting industry. However, various factors create numerous obstacles that hinder this model’s effective promotion and application. One essential task is to deeply analyze the transmission mechanism of the influencing factors in the promotion and application of WPEC, and explore effective pathways for promoting and applying this model. This paper systematically organizes and summarizes 10 primary influencing factors and 38 secondary influencing factors for promoting WPEC. Using the complex network analysis method, a network of influencing factors for promoting WPEC, a network structure, and motif analyses are conducted. The results show that the influencing factors have a complex transmission mechanism, and complex network analysis can reveal the laws of their construction and their causes. This paper provides a systematic basis and theoretical support for the effective formulation of policies related to the promotion and application of WPEC. Full article

This study evaluates a hybrid heating system in a single-family building in northeastern Poland, which has a temperate continental climate. The analysis covers two heating seasons in 2021/2022 and 2022/2023. The hybrid heating system includes an air heat pump HPA–08 CS Plus with a heating power of 8.2 kW (AHP), a condensing gas boiler VC146/5–5 with a power of 14 kW (GB–Condens.), and a solid fuel boiler with a power of 11 kW for central heating. Additionally, hot water is heated by a Basic 270 (DHW’s AHP) air–water heat pump with a power of 2 kW, utilizing a tank with a capacity of 270 dm³ equipped with two heating coils. The building’s average electricity consumption is around 5400 kWh/year. A 4.96 kWp photovoltaic installation is installed on the building’s roof at a 40° angle towards the south to supplement the hybrid system. The study aims to assess whether the PV installation can adequately cover the energy needs of the hybrid heat source for heating and hot water. Furthermore, the study calculates the emission of pollutants (CO₂, SO_x, NO_x, CO, and PM10) into the atmosphere. The total annual electricity production from PV installations was 5444.9 kWh in 2021/2022 and 5684.8 kWh in 2022/2023. The excess electricity was stored in the PGE power grid as per the Prosumer settlement rules. The installed PV installation is sufficient to power the following devices annually: AHP, DHW’s AHP, and GB–Condens. However, the daily electricity production from the PV installation is not enough to cover the energy needs of the heat pump for heating during the cold months in Poland (I–III, XI–XII). It can meet the power needs of a PC all year round and can also be stored during the summer months, for example, in energy warehouses or by directly storing it in the PGE power grid. The use of the PV installation resulted in an average reduction in pollutant emissions into the atmosphere: CO₂—94.1%, SO_x—91.8%, NO_x—95.6%, CO—9.7%, and PM10—32.1%. Full article

In this note, we study skew cyclic and skew constacyclic codes over the mixed alphabet $\mathcal{R}={\mathbb{F}}_q{\mathcal{R}}_1{\mathcal{R}}_2$, where $q=p^m,$ p is an odd prime with m odd and ${\mathcal{R}}_1={\mathbb{F}}_q+u{\mathbb{F}}_q$ with $u^2=u$, and ${\mathcal{R}}_2={\mathbb{F}}_q+u{\mathbb{F}}_q+v{\mathbb{F}}_q$ with $u^2=u,v^2=v,uv=vu=0.$ Such codes consist of the juxtaposition of three codes of the same size over ${\mathbb{F}}_q,$${\mathcal{R}}_1,$ and ${\mathcal{R}}_2$, respectively. We investigate the generator polynomial for skew cyclic codes over $\mathcal{R}$. Furthermore, we discuss the structural properties of the skew cyclic and skew constacyclic codes over $\mathcal{R}.$ We also study their q-ary images under suitable Gray maps. Full article

Meat characterized by a high marbling value is typically anticipated to display enhanced sensory attributes. This study aimed to predict the marbling scores of rib-eye, steaks sourced from the Longissimus dorsi muscle of different cattle types, namely Boran, Senga, and Sheko, by employing digital image processing and machine-learning algorithms. Marbling was analyzed using digital image processing coupled with an extreme gradient boosting (GBoost) machine learning algorithm. Meat texture was assessed using a universal texture analyzer. Sensory characteristics of beef were evaluated through quantitative descriptive analysis with a trained panel of twenty. Using selected image features from digital image processing, the marbling score was predicted with R² (prediction) = 0.83. Boran cattle had the highest fat content in sirloin and chuck cuts (12.68% and 12.40%, respectively), followed by Senga (11.59% and 11.56%) and Sheko (11.40% and 11.17%). Tenderness scores for sirloin and chuck cuts differed among the three breeds: Boran (7.06 ± 2.75 and 3.81 ± 2.24, respectively), Senga (5.54 ± 1.90 and 5.25 ± 2.47), and Sheko (5.43 ± 2.76 and 6.33 ± 2.28 Nmm). Sheko and Senga had similar sensory attributes. Marbling scores were higher in Boran (4.28 ± 1.43 and 3.68 ± 1.21) and Senga (2.88 ± 0.69 and 2.83 ± 0.98) compared to Sheko (2.73 ± 1.28 and 2.90 ± 1.52). The study achieved a remarkable milestone in developing a digital tool for predicting marbling scores of Ethiopian beef breeds. Furthermore, the relationship between quality attributes and beef marbling score has been verified. After further validation, the output of this research can be utilized in the meat industry and quality control authorities. Full article

Evaluating the vulnerability of urban transportation systems to flood disasters can provide scientific support for urban disaster prevention and mitigation. Current methods for assessing the flood vulnerability of urban roads often overlook the internal relationships within the complex spatial composition of road networks and surface structures. In this study, based on the theory of complex networks, a dual-layer network assessment model is established for evaluating the flood vulnerability of urban transportation systems by coupling basic geographic data with road network vector data. Unlike traditional methods, this model considers the complex relationship between road network structures and ground surfaces, uncovering a correlation between road network structure and road flood vulnerability. By utilizing this model, the flood vulnerability of road networks in Shenzhen, as well as the city’s spatial flood vulnerability, are quantitatively assessed. Based on the quantitative results, we create maps illustrating the distribution of road and spatial flood vulnerability in Shenzhen. The study results reflect that roads highly vulnerable to flooding are mainly located in the central urban area of the southwest, with the flood vulnerability spatially concentrated primarily in the northern and western regions. Using data from government reports, news stories, and other sources over the past five years, we compile recorded instances of urban waterlogging. The quantitative results of the model are consistent with the distribution trend in recorded waterlogging points, indicating that the model’s outcomes are authentic and reliable. Full article

In this study, we critically examine the potential of recycled construction materials, focusing on how these materials can significantly reduce greenhouse gas (GHG) emissions and energy usage in the construction sector. By adopting an integrated approach that combines Life Cycle Assessment (LCA) and Material Flow Analysis (MFA) within the circular economy framework, we thoroughly examine the lifecycle environmental performance of these materials. Our findings reveal a promising future where incorporating recycled materials in construction can significantly lower GHG emissions and conserve energy. This underscores their crucial role in advancing sustainable construction practices. Moreover, our study emphasizes the need for robust regulatory frameworks and technological innovations to enhance the adoption of environmentally responsible practices. We encourage policymakers, industry stakeholders, and the academic community to collaborate and promote the adoption of a circular economy strategy in the building sector. Our research contributes to the ongoing discussion on sustainable construction, offering evidence-based insights that can inform future policies and initiatives to improve environmental stewardship in the construction industry. This study aligns with the European Union’s objectives of achieving climate-neutral cities by 2030 and the United Nations’ Sustainable Development Goals outlined for completion by 2030. Overall, this paper contributes to the ongoing dialogue on sustainable construction, providing a fact-driven basis for future policy and initiatives to enhance environmental stewardship in the industry. Full article

The occurrence of antibiotic-resistant bacteria in foodstuff involves a human health risk. Edible insects are a precious resource; however, their consumption raises food safety issues. In this study, the occurrence of antibiotic resistant bacteria in laboratory-reared fresh mealworm larvae (Tenebrio molitor L.) and frass was assessed. Antibiotics were not used during the rearing. Enterobacteriaceae and enterococci were isolated from 17 larvae and eight frass samples. In total, 62 and 69 isolates presumed to belong to Enterobacteriaceae and Enterococcus spp., respectively, were obtained and tested for antibiotic susceptibility via disk diffusion. Based on the results, isolates were grouped, and representative resistant isolates were identified at species level through 16S rRNA gene sequencing. For enterococci resistance, percentages higher than 15% were observed for vancomycin and quinupristin–dalfopristin, whereas Enterobacteriaceae resistance higher than 25% was found against cefoxitin, ampicillin, and amoxicillin–clavulanic acid. Based on the species identification, the observed resistances seemed to be intrinsic both for enterococci and Enterobacteriaceae, except for some β-lactams resistance in Shigella boydii (cefoxitin and aztreonam). These could be due to transferable genetic elements. This study suggests the need for further investigations to clarify the role of edible insects in the spreading of antibiotic resistance determinants through the food chain. Full article

Background: Pediatric colorectal specialists care for patients with a variety of defecation disorders. Anorectal (AR) manometry testing is a valuable tool in the diagnosis and management of these children. This paper provides a summary of AR manometry techniques and applications as well as a review of AR manometry findings in pediatric patients with severe defecation disorders referred to a pediatric colorectal center. This is the first study describing multi-year experience using a portable AR manometry device in pediatric patients. Methods: An electronic medical record review was performed (1/2018 to 12/2023) of pediatric patients with defecation disorders who had AR manometry testing. Demographics, diagnostic findings, and outcomes are described. Key Results: A total of 297 unique patients (56.9% male, n = 169) had AR manometry testing. Of these, 72% (n = 188) had dyssynergic defecation patterns, of which 67.6% (n = 127) had fecal soiling prior to treatment. Pelvic rehabilitation (PR) was administered to 35.4% (n = 105) of all patients. A total of 79.5% (n = 58) of the 73 patients that had fecal soiling at initial presentation and completed PR with physical therapy and a bowel management program were continent after therapy. AR manometry was well tolerated, with no major complications. Conclusions: AR manometry is a simple test that can help guide the management of pediatric colorectal surgical patients with defecation disorders. As a secondary finding, PR is a useful treatment for patients with dyssynergic stooling. Full article

The problem of normal impact of a rigid sphere on a Maxwell viscoelastic solid half-space is considered. The first-order asymptotic solution is constructed in the framework of Hunter’s model of viscoelastic impact. In particular, simple analytical approximations have been derived for the maximum contact force and the time to achieve it. A linear regression method is suggested for evaluating the instantaneous elastic modulus and the mean relaxation time from a set of experimental data collected for different spherical impactors and impact velocities. Full article

The Danjiangkou Reservoir is the water source of the middle route of China’s South-to-North Water Diversion Project, encompassing the Dan Reservoir and Han Reservoir. However, little is known about the ecological functions of this important ecosystem. Based on a survey conducted in 2023 in the Dan Reservoir, a mass balance model was constructed using Ecopath with Ecosim 6.6 software to characterize its food web structure and ecosystem properties. The model consisted of 18 functional groups, including producers, consumers, and detritus, covering the entire process of energy flow in the ecosystem. The outputs indicated that the fractional trophic level of functional groups in the Dan Reservoir ecosystem ranged from 1.00 to 3.50. The ecotrophic efficiencies of the main economic fish species were all less than 0.9, and the ecotrophic efficiencies of phytoplankton and detritus were less than 0.5. There were two main food chains: the detritus food chain (39%) and the grazing food chain (61%). The total energy transfer efficiency between trophic levels was only 6.02%, and there was a significant phenomenon of energy transfer blockage between trophic levels II and V. Analysis of the overall characteristics of the ecosystem revealed that the total primary production to total biomass (67.96619), connectance index (0.274), and Finn’s cycling index (2.856) of the Dan Reservoir ecosystem all indicate that the ecosystem is immature, with low nutrient recycling efficiency and poor resistance to external disturbances. This may be related to the low proportion of silver carp and bighead carp in the reservoir and the unreasonable structure of the fish community. Our results suggest that it is necessary to scientifically adjust the structure of the fish community, enhance the proportion of filter-feeding and omnivorous fish to improve the energy flow efficiency, and promote the maturity and stability of the Dan Reservoir. Full article

Background: the ABCD2 score is valuable for predicting early stroke recurrence after a transient ischemic attack (TIA), and Doppler ultrasound can aid in expediting stroke triage. The study aimed to investigate whether combining the ABCD2 score with carotid duplex results can enhance the identification of early acute ischemic stroke after TIA. Methods: we employed a retrospective cohort design for this study, enrolling patients diagnosed with TIA who were discharged from the emergency department (ED). The modified ABCD2-I (c50) score, which incorporates a Doppler ultrasound assessment of internal carotid artery stenosis > 50%, was used to evaluate the risk of acute ischemic stroke within 72 h. Patients were categorized into three risk groups: low risk (with ABCD2 and ABCD2-I scores = 0–4), moderate risk (ABCD2 score = 4–5 and ABCD2-I score = 5–7), and high risk (ABCD2 score = 6–7 and ABCD2-I score = 8–9). Results: between 1 January 2014, and 31 December 2019, 1124 patients with new neurological deficits were screened, with 151 TIA patients discharged from the ED and included in the analysis. Cox proportional hazards analysis showed that patients in the high-risk group, as per the ABCD2-I (c50) score, were significantly associated with revisiting the ED within 72 h due to acute ischemic stroke (HR: 3.12, 95% CI: 1.31–7.41, p = 0.0102), while the ABCD2 alone did not show significant association (HR: 1.12, 95% CI: 0.57–2.22, p = 0.7427). Conclusion: ABCD2-I (c50) scores effectively predict early acute ischemic stroke presentations to the ED within 72 h after TIA. Full article

In the dynamic landscape of autonomous transport, the integration of intelligent transport systems and embedded control technology is pivotal. While strides have been made in the development of autonomous agents and multi-agent systems, the unique challenges posed by two-wheeled vehicles remain largely unaddressed. Dedicated control strategies for these vehicles have yet to be developed. The vertical balance of an autonomous two-wheeled single-track vehicle is a challenge for engineering. This type of vehicle is unstable and its dynamic behaviour changes with the forward velocity. We designed a scheduled-gain proportional–integral controller that adapts its gains to the forward velocity, maintaining the vertical balance of the vehicle by means of the steering front-wheel angle. The control law was tested with a prototype designed by the authors under different scenarios, smooth and uneven floors, maintaining the vertical balance in all cases. Full article

Extended Reality (XR) is increasingly gaining momentum in industries such as retail, health, and education. To protect users’ personal data, establishing a secure authentication system for XR devices becomes essential. Recently, the focus on authentication methods for XR devices has been limited. To further our understanding of this topic, we surveyed authentication schemes, particularly systems and methods deployed in XR settings. In this survey, we focused on reviewing and evaluating papers published during the last decade (between 2014 and 2023). We compared knowledge-based authentication, physical biometrics, behavioral biometrics, and multi-model methods in terms of accuracy, security, and usability. We also highlighted the benefits and drawbacks of those methods. These highlights will direct future Human–computer Interaction (HCI) and security research to develop secure, reliable, and practical authentication systems. Full article

Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. The objective of this study was to characterize the safety and efficacy of romidepsin as consolidation therapy after gemcitabine, dexamethasone, and cisplatin (GDP) therapy (GDPR). This study of patients treated between March 2019 and March 2021 was registered with the Japan Registry of Clinical Trials (registration number: jRCT0000000519). If complete response, partial response, or stable disease was confirmed after 2–4 GDP cycles, romidepsin was administered every 4 weeks for 1 year. Seven patients with relapsed/refractory (R/R) PTCL (T-follicular helper phenotype [n = 1] and angioimmunoblastic T-cell lymphoma [n = 6]) were included in this prospective study (PTCL-GDPR). After a median follow-up of 34 months of patients in PTCL-GDPR, the 2-year overall survival rate was 71%, and the overall response rate after treatment was 57%. Common adverse events in patients with PTCL-GDPR included hematological toxicities such as neutropenia, which improved with supportive treatment. There were no treatment-related mortalities. GDPR might be safe and effective in elderly transplant-ineligible patients with R/R PTCL; however, further investigation is required. Full article

The many limitations of implementing anticancer strategies under the term “precision oncology” have been extensively discussed. While some authors propose promising future directions, others are less optimistic and use phrases such as illusion, hype, and false hypotheses. The reality is revealed by practicing clinicians and cancer patients in various online publications, one of which has stated that “in the quest for the next cancer cure, few researchers bother to look back at the graveyard of failed medicines to figure out what went wrong”. The message is clear: Novel therapeutic strategies with catchy names (e.g., synthetic “lethality”) have not fulfilled their promises despite decades of extensive research and clinical trials. The main purpose of this review is to discuss key challenges in solid tumor therapy that surprisingly continue to be overlooked by the Nomenclature Committee on Cell Death (NCCD) and numerous other authors. These challenges include: The impact of chemotherapy-induced genome chaos (e.g., multinucleation) on resistance and relapse, oncogenic function of caspase 3, cancer cell anastasis (recovery from late stages of apoptosis), and pitfalls of ubiquitously used preclinical chemosensitivity assays (e.g., cell “viability” and tumor growth delay studies in live animals) that score such pro-survival responses as “lethal” events. The studies outlined herein underscore the need for new directions in the management of solid tumors. Full article

Popularity is of great developmental significance to early adolescents for its implications on behavioral and adjustment outcomes. Although extensive research on popularity has been conducted in Western cultures, little is known about Chinese adolescents’ indigenous understanding of popularity. The current study examined Chinese early adolescents’ understanding of popularity using focus group interviews to explore the characteristics of popularity and unpopularity, as well as popularity determinants for boys and girls. We conducted interviews on six focus groups comprising 37 Chinese fifth and sixth graders (18 boys, 19 girls). Transcriptions were coded and analyzed through developing coding schemes that included emerged codes and categories. The results showed both cross-cultural similarities and culturally specific findings in adolescents’ perceptions of popularity characteristics and determinants. Specifically, sociability, academic performance, and prosocial behaviors served as major characteristics of popularity, whereas aggressive and disruptive behaviors were regarded as typical attributes of unpopularity. More importantly, culturally unique aspects of popularity characteristics were reported by Chinese adolescents, such as a strong sense of collective honor. When responding what would make a peer popular, Chinese early adolescents reported various behavioral, social, and cultural factors. Findings of this study underscore the importance of examining perceptions of popularity in consideration of the cultural context. Full article

Worldwide, nurse shortages constitute a problem, including in the Netherlands. Every region in the country has a shortage of all types of nurses. At the same time, there are large hidden reserves: persons who have been trained as a nurse but do not work in the healthcare sector. The size of the hidden reserve exceeds the shortage of nurses. Until now, the literature has not paid much attention to spatial aspects of the nursing shortage problem. In this paper, we analyze the size of the hidden reserves and how they are distributed over the country, across large and smaller cities, and across different nurse categories. We find that especially densely populated areas have relatively small shares of trained nurses as well as large hidden reserves relative to their population. These areas are also facing the largest nurse shortages. As nurse labor markets are local, policies that are more focused on local situations are necessary to activate these hidden reserves. Full article