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Modification of Automatic Synthesis of [18F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module

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Radiochemistry Aims and scope

Abstract

A procedure for preparing 1-(2-hydroxy-3-[18F]fluoropropyl)-2-nitroimidazole ([18F]fluoromisonidazole, [18F]FMISO) on a commercially available GE TracerLAB Fx F-N synthesis module was developed. The product obtained meets all the requirements of the European Pharmacopoeia (8th ed.) for clinical use. Its decay-corrected radiochemical yield is 59 ± 4% (n = 5).

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Authors and Affiliations

  1. Almazov Northwest Federal Medical Research Center, Ministry of Health of the Russian Federation, ul. Akkuratova 2, St. Petersburg, 197341, Russia

    D. O. Antuganov, D. V. Ryzhkova, T. A. Zykova, V. V. Timofeev, Yu. O. Antuganova, K. Yu. Timofeeva, O. P. Samburov & M. P. Zykov

Authors
  1. D. O. Antuganov
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  2. D. V. Ryzhkova
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  3. T. A. Zykova
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  4. V. V. Timofeev
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  5. Yu. O. Antuganova
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  6. K. Yu. Timofeeva
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  7. O. P. Samburov
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  8. M. P. Zykov
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Corresponding author

Correspondence to D. O. Antuganov.

Additional information

Original Russian Text © D.O. Antuganov, D.V. Ryzhkova, T.A. Zykova, V.V. Timofeev, Yu.O. Antuganova, K.Yu. Timofeeva, O.P. Samburov, M.P. Zykov, 2018, published in Radiokhimiya, 2018, Vol. 60, No. 1, pp. 44–48.

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Antuganov, D.O., Ryzhkova, D.V., Zykova, T.A. et al. Modification of Automatic Synthesis of [18F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module. Radiochemistry 60, 45–50 (2018). https://doi.org/10.1134/S1066362218010083

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  • DOI: https://doi.org/10.1134/S1066362218010083

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