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Neuroendocrine carcinoma of the stomach: clinical features and CT findings

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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of the study is to investigate the computed tomographic characteristic and clinical findings of gastric neuroendocrine carcinoma (G-NEC) to increase awareness of this disease.

Methods

Twenty-two patients with a diagnosis of G-NEC were identified through the PACS of our hospital from August 2010 to November 2014. The clinical data, computed tomography (CT) features, and pathology records were analyzed.

Results

Among the 22 patients, 21 were male (95.45%), and 1 was female (4.55%). The mean age was 63.5 years old. Positive rates of neuroendocrine markers were 77.28% for chromogranin A staining, 86.36% for synaptophysin staining. All cases were single lesions including 16 (72.73%) in the gastric fundus, 3 (13.64%) in the gastric body and 1 (4.55%) in the gastric angle. Additionally 2 (9.09%) were found in the gastric antrum. Gastric wall was local thickening in 15 cases, and mass formation in 7 cases, with the stenosis and deformation of the adjacent gastric cavity. The long-axis diameter of the lesions ranged from 1.2 to7.4 cm (mean diameter, 2.47 cm), and the long-axis diameter was <2 cm in 12 case, 2–7.4 cm in 10 cases. The radiodensity values of the lesions were homogeneous density in 15 cases ranging from 22 to 47 HU (mean 34 HU). An ulcer with an irregular base and slightly raised borders located in the stomach was seen in 19 cases. The CT images showed homogeneous enhancement in 15 cases and heterogeneous enhancement in 7 cases. Obvious enhancement was seen in two cases, moderate enhancement was seen in sixteen cases, and mildly enhancement was seen in four cases. The peak value occurred in the arterial phase in 5 cases and the peak value was seen in 17 cases in the portal phase. Eleven lesions invaded the gastric serosa, and lymphatic metastasis was observed in 21 cases, 8 of which were combined with liver metastasis. CT images revealed 2 cases of the liver metastasis had obvious enhancement.

Conclusion

The CT features regarding location, incidence rates of ulcer and enhancement pattern described in our findings are common in all malignant gastric tumors. Therefore, the diagnosis of G-NEC must be confirmed with pathological test.

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Abbreviations

CT:

Computed tomography

G-NEC:

Gastric neuroendocrine carcinoma

NENs:

Neuroendocrine neoplasms

NEC:

Neuroendocrine carcinoma

References

  1. Oberndorfer S (1907) Karzinoide Tumoren des Dünndarms. Frankf Z Pathol 1:425–432

    Google Scholar 

  2. Li TT, Qiu F, Qian ZR, et al. (2014) Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors. World J Gastroenterol 20(1):118–125

    Article  PubMed Central  PubMed  Google Scholar 

  3. Scoazec JY, Couvelard A (2011) The new WHO classification of digestive neuroendocrine tumors. Ann Pathol 31(2):88–92

    Article  PubMed  Google Scholar 

  4. Jiang SX, Mikami T, Umezawa A, et al. (2006) Gastric large cell neuroendocrine carcinomas: a distinct clinicopathologic entity. Am J Surg Pathol 30(8):945–953

    Article  PubMed  Google Scholar 

  5. Miguchi M, Iseki M, Shimatani K (2012) Advanced gastric neuroendocrine carcinoma with an adenocarcinoma component. Case Rep Gastroenterol 6(1):52–57

    Article  PubMed Central  PubMed  Google Scholar 

  6. Makis W, Ciarallo A, Hickeson M, et al. (2013) Gastric neuroendocrine carcinoma staged and followed with (18)F-FDG PET/CT–a report of 3 cases. Clin Nucl Med. 38(6):447–450

    Article  PubMed  Google Scholar 

  7. Watanabe N, Kato H, Shimizu M, et al. (2006) F-18 FDG PET imaging in gastric neuroendocrine carcinoma. Clin Nucl Med 31(6):345–346

    Article  PubMed  Google Scholar 

  8. Wang D, Zhang GB, Yan L, et al. (2012) CT and enhanced CT in diagnosis of gastrointestinal neuroendocrine carcinomas. Abdom Imaging 37(5):738–745

    Article  PubMed  Google Scholar 

  9. Xu X, Li J, Han X, et al. (2014) Clinical characteristics and prognostic factors of patients with gastric neuroendocrine carcinoma treated with radical surgery. Chin Med J (Engl) 127(13):2419–2422

    Google Scholar 

  10. Namikawa T, Oki T, Kitagawa H, et al. (2013) Neuroendocrine carcinoma of the stomach: clinicopathological and immunohistochemical evaluation. Med Mol Morphol. 46(1):34–40

    Article  CAS  PubMed  Google Scholar 

  11. Endo S, Dousei T, Yoshikawa Y, et al. (2012) Gastric neuroendocrine tumors in our institutions according to the WHO 2010 classification. Int Surg 97(4):335–339

    Article  PubMed Central  PubMed  Google Scholar 

  12. Uchiyama C, Tamura S, Nakatsuka S, et al. (2012) Immunohistochemical consistency between primary tumors and lymph node metastases of gastric neuroendocrine carcinoma. World J Surg Oncol 10:115

    Article  PubMed Central  PubMed  Google Scholar 

  13. Ishida M, Sekine S, Fukagawa T, et al. (2013) Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis. Am J Surg Pathol 37(7):949–959

    Article  PubMed  Google Scholar 

  14. Kang SH, Kim KH, Seo SH, et al. (2014) Neuroendocrine carcinoma of the stomach: a case report. World J Gastrointest Surg 6(4):77–79

    PubMed Central  PubMed  Google Scholar 

  15. DelleFave G, Kwekkeboom DJ, Van Cutsem E, et al. (2012) ENETS consensus guidelines for the management of patients with gastroduodenal neoplasms. Neuroendocrinology 95(2):74–87

    Article  CAS  Google Scholar 

  16. Karakoyun R, Demirci E, Karakoyun M, et al. (2014) Reliability of MDCT, with MPR and hydro-CT technique, in resectability and lymphnode staging of gastric cancer. Minerva Chir 69(3):129–140

    CAS  PubMed  Google Scholar 

  17. Cidón EU, Cuenca IJ (2009) Gastric adenocarcinoma: is computed tomography (CT) useful in preoperative staging? Clin Med Oncol 3:91–97

    PubMed Central  PubMed  Google Scholar 

  18. Huang WL, Li YG, Lv YC, et al. (2014) Use of lectin microarray to differentiate gastric cancer from gastric ulcer. World J Gastroenterol 20(18):5474–5482

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Wu J, Zhu H, Li K, et al. (2014) 18F-fluorodeoxyglucose positron emission tomography/computed tomography findings of gastric lymphoma: comparisons with gastric cancer. Oncol Lett 8(4):1757–1764

    PubMed Central  PubMed  Google Scholar 

  20. Gossios K, Katsimbri P, Tsianos E (2000) CT features of gastric lymphoma. Eur Radiol 10(3):425–430

    Article  CAS  PubMed  Google Scholar 

  21. Ovali GY, Tarhan S, Serter S, et al. (2005) Gastric stromal tumor. Diagn Interv Radiol 11(2):102–104

    PubMed  Google Scholar 

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Acknowledgment

This work was supported the National Natural Science Foundations of China (81271573).

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Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital, Zhengzhou University, No.1. Eastern Jianshe Road, Zhengzhou, 450052, China

    Pan Liang, Yi-Xu Wang, Xiu-Chun Ren & Jian-Bo Gao

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  1. Pan Liang
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  2. Yi-Xu Wang
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Correspondence to Jian-Bo Gao.

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Liang, P., Wang, YX., Ren, XC. et al. Neuroendocrine carcinoma of the stomach: clinical features and CT findings. Abdom Radiol 41, 19–24 (2016). https://doi.org/10.1007/s00261-015-0593-7

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