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免疫治疗是晚期非小细胞肺癌去化疗的关键,或还是未到时候?

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)改变了缺乏驱动基因突变的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗... More >>

晚期或转移性非小细胞肺癌一线免疫治疗中,肿瘤细胞PD-L1表达的阈值究竟在哪

对于晚期或转移性非小细胞肺癌(non-small cell lung cancer,NSCLC),一线免疫治疗对部分患者来说,可以获得比单纯化疗更好的总生存率获益。 More >>

KEYNOTE-042研究:降低帕博利珠单抗单药一线治疗的PD-L1阈值是个好主意吗?

在针对程序性死亡1(programmed death 1,PD-1)或程序性死亡配体1(programmed death ligand 1,PD-L1)的抑制性抗体出现之前,晚期/转移性非小细胞肺癌(... More >>

Editorial

Extended lobectomy—how minimally invasive can we go?
Koen C. H. A. Verkoulen, Jean H. T. Daemen, Iris E. W. G. Laven, Karel W. E. Hulsewé, Yvonne L. J. Vissers, Erik R. de Loos

Original Article

Contribution of crosstalk of mesothelial and tumoral epithelial cells in pleural metastasis of lung cancer
Pei-Heng Li, Xin Zhang, Huayun Yan, Xuyang Xia, Yiqi Deng, Qiang Miao, Yiqiao Luo, Guihong Liu, Han Luo, Yan Zhang, Heng Xu, Lili Jiang, Zhi-Hui Li, Yang Shu
Comprehensive analysis of next generation sequencing and ARMS-PCR for detecting EGFR exon 20 insertion (ex20ins) mutations in Chinese non-small cell lung cancer patients
Yuyin Xu, Liqing Jia, Ling Zhang, Haochen Wang, Lin Jiang, Xu Feng, Ran Wei, Qianlan Yao, Min Ren, Tian Xue, Yuan Li, Xiaoli Zhu, Xiaoyan Zhou, Qianming Bai
Development of a predictive model to predict postoperative bone metastasis in pathological I–II non-small cell lung cancer
Jian Zhou, Dongsheng Wu, Quan Zheng, Tengyong Wang, Jiandong Mei
GPRC5A is a potential prognostic biomarker and correlates with immune cell infiltration in non-small cell lung cancer
Yicong Lin, Yue Wang, Qianqian Xue, Qiang Zheng, Lijun Chen, Yan Jin, Ziling Huang, Yuan Li
CDK4/6 inhibitor abemaciclib combined with low-dose radiotherapy enhances the anti-tumor immune response to PD-1 blockade by inflaming the tumor microenvironment in Rb-deficient small cell lung cancer
Laduona Wang, Yijun Wu, Kai Kang, Xuanwei Zhang, Ren Luo, Zegui Tu, Yue Zheng, Guo Lin, Hui Wang, Min Tang, Min Yu, Bingwen Zou, Ruizhan Tong, Linglu Yi, Feifei Na, Jianxin Xue, Zhuoran Yao, You Lu
Race, age at diagnosis and histological characteristics of lung cancer in never-smokers (LCINS) and ever-smokers in low-dose computed tomography (LDCT) screening: a systematic review and meta-analysis
Natthaya Triphuridet, Misako Nagasaka, Elaine Shum, Sai-Hong Ignatius Ou
Pleural carbohydrate antigen 50 and malignant pleural effusion: a prospective, double-blind diagnostic accuracy test
Su-Na Cha, Yan Niu, Jian-Xun Wen, Cheng Yan, Qian Yang, Hong-Zhe Zhu, Xi Lin, Xi-Shan Cao, Wen-Hui Gao, Ya-Fei Wang, Feng Zhou, Li Yan, Wen-Qi Zheng, Zhi-De Hu
Clinical predictors of severe radiation pneumonitis in patients undergoing thoracic radiotherapy for lung cancer
Yujie Yan, Yaoyao Zhu, Shuangyan Yang, Cheng Qian, Ying Zhang, Xiaoshuai Yuan, Min Hu, Jingjing Kang, Chenxue Jiang, Minren Hu, Ruifeng Zhao, Lan Zhao, Yaping Xu
Identification of a novel prognostic signature based on vitamin metabolism clustering-related genes in lung adenocarcinoma
Yu Chen, Yupeng Jiang, Xionghui Li, Hong Huang, Yangying Zhou, Chenzi Zhang, Shunjun Wang, Hanibal Bohnenberger, Yawen Gao
Contrast-enhanced CT and PET-CT characteristics of primary tracheal lymphoepithelioma-like carcinoma: case series
Qin Liu, Fanrui Zeng, Chongxiang Peng, Yuhua Lin, Qiong Wang, Qingsi Zeng

Brief Report

Outcomes of initial therapy for synchronous brain metastases from small cell lung cancer: a single-institution retrospective analysis
Kevin V. Chaung, Michael Z. Kharouta, Andrew J. Gross, Pingfu Fu, Mitchell Machtay, Tiffany R. Hodges, Andrew E. Sloan, Tithi Biswas, Afshin Dowlati, Serah Choi

Case Report: iMDT Corner

A rare case report of a primary lung cancer comprising adenocarcinoma and atypical carcinoid tumor, with the carcinoid component harboring EML4-ALK rearrangement
Wenbin Hu, Jiaming Zhao, Guoxia Wang, Qihao Wang, Mingming Deng, Jie Shen, Paul Hofman, Edyta Maria Urbanska, Eric Santoni-Rugiu, Petros Christopoulos, Robert A. Ramirez, Toyoaki Hida, Xiaoqing Lu, Binjun He

Case Report

A novel HLA-DQB2::MET gene fusion variant in lung adenocarcinoma with prolonged response to tepotinib: a case report
Douglas Dias e Silva, Isa Mambetsariev, Jeremy Fricke, Razmig Babikian, Shaira Therese Dingal, Farhad Mazdisnian, Behnam Badie, Leonidas Arvanitis, Michelle Afkhami, Miguel Villalona-Calero, Ravi Salgia

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

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