1988 Volume 35 Issue 5 Pages 775-781
Four patients with GH deficiency aged 6-14 years old were treated with hGRF for 6months. Before the treatment maximal plasma GH responses to 50μg iv hGRF administration were 48.6, 12.1, 24.3 and 13.0ng/ml, respectively. Human GRF was administered at a dosage of 50-100μg twice a day subcutaneously. In two patients, the growth rate was increased from 2.4 and 2.0cm/year to 8.2 and 9.8cm/year, respectively. In the other two patients, the growth rate did not change with hGRF treatment. Plasma somatomedin C levels increased in one patient but did not change in the other three. Antibody to hGRF was observed in two patients during the treatment, but the presence of antibody did not affect the growth rate.
