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Elevated Neutrophil/Lymphocyte Ratio in Adolescents with Early-onset Schizophrenia

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Abstract—

Inflammation plays a substantial role in the pathophysiology of schizophrenia. The neutrophil to lymphocyte ratio (NLR) is a cost-effective and simple indicator of inflammation, which it is widely used as a proxy of systemic inflammation. In this retrospective study, we investigated the relationship between NLR and early-onset schizophrenia. Hematologic parameters and Positive and Negative Syndrome Scale (PANSS) scores were obtained from the medical records of 32 patients. NLR values and hematologic parameters were compared with 32 age- and sex-matched healthy controls. The mean NLR was significantly higher in patients than in controls. The neutrophil count was significantly higher in the patient group; however, leukocyte, haemoglobin, lymphocyte, and platelet counts did not differ between groups. No significant correlation was found between PANSS scores and NLR in the patient group. Our findings suggest that elevated NLR is an inflammation biomarker that plays a role in the pathophysiology of schizophrenia.

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey

    Arif Önder, Aslı Sürer Adanır & Özge Gizli Çoban

  2. Child and Adolescent Psychiatry, Manisa Mental Health and Diseases Hospital, Manisa, Turkey

    Öznur Bilaç & Canem Kavurma

Authors
  1. Arif Önder
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  2. Aslı Sürer Adanır
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  3. Özge Gizli Çoban
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  4. Öznur Bilaç
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  5. Canem Kavurma
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Correspondence to Arif Önder.

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Conflict of interest. The authors declare that they have no conflict of interest.

Ethical approval. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent. This retrospective study was approved by the Institutional Ethics Committee of Akdeniz University. This is a retrospective study and therefore does not required informed consent. This article does not contain any studies with human participants or animals performed by any of the authors.

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Arif Önder, Adanır, A.S., Çoban, Ö.G. et al. Elevated Neutrophil/Lymphocyte Ratio in Adolescents with Early-onset Schizophrenia. Neurochem. J. 14, 444–448 (2020). https://doi.org/10.1134/S1819712420330016

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  • DOI: https://doi.org/10.1134/S1819712420330016

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