Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Comparative Study of Cefuzonam (CZON) with Cefotiam in Bacterial Pneumonia and Pulmonary Suppuration
Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, [in Japanese], Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, Masao NAKATOMI
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Keywords: Cefuzonam, Cefotiam Bacterial Pneumoniae Comparative study
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1986 Volume 60 Issue 8 Pages 885-910

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Abstract

A comparative study was conducted to objectively evaluate the efficacy and safety of Cefuzonam (CZON) with Cefotiam (CTM) used as a control drug. Subjected diseases were bacterial pneumonia and pulmonary suppuration. Each drug was administered by intravenous drip infusion 1g at a time, twice a day, for 14 days as a rule. The following are the results:
1. A total of 235 patients, 117 of CZON group and 118 of CTM group, were treated, but subjected for clinical efficacy assessment by the efficacy evaluation committee were 187 cases, 99 of CZON group and 88 of CTM group, 48 cases were excluded from the evaluation.
2. Overall clinical efficacy rates were 63.3% for CZON group and 69.0% for CTM group, with no significant difference shown between the two drug groups.
3. Clinical efficacy classified by causal bacteria showed no significant difference between the two drug groups. Bacterial eradication rates were as high as 95.2% for CZON and 80.0% for CTM, but there was no significant difference between the two.
4. Against causal bacteria, MICs of CZON were significantly superior to those of CTM.
5. As for side effects incidence and abnormality in laboratory test values, no significant difference was observed between the two groups.
6. Usefulness rate for CZON was 62.2%, whereas that for CTM was 67.8%, showing no significant difference.
From these results, CZON was proved to be a useful drug for bacterial pneumonia and pulmonary suppuration.

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