急性肺炎に対するClindamycin phosphateとLincomycin hydrochlorideの薬効比較試験成績 (第2報) 二重盲検法による比較

中川 圭一; 小山 優; 伊藤 勝仁; 山本 敬; 上田 雅己; 福井 洸; 斉藤 玲; 中山 一朗; 富沢 磨須美; 松井 克彦; 阿部 守邦; 武部 和夫; 吉田 秀一郎; 岡本 勝博; 高橋 英子; 小坂 志朗; 八代 均; 藤岡 譲; 増田 光男; 渡辺 肇; 村上 誠一; 貴田岡 正史; 遠藤 勝実; 田村 豊一; 遅野井 健; 林 雅人; 進藤 千代彦; 村上 太平; 佐藤 泰朗; 林 泉; 山作 房之輔; 鈴木 康稔; 関根 理; 薄田 芳丸; 青木 信樹; 金沢 裕; 勝 正孝; 奥井 津二; 早川 正勝; 可部 順三郎; 藤森 一平; 小林 芳夫; 竹田 義彦; 大山 馨; 大久保 滉; 岡本 緩子; 上田 良弘; 前原 敬悟; 副島 林造; 二木 芳人; 森 博雄; 山崎 和子; 沢江 義郎; 松本 慶蔵; 鈴木 寛; 山本 眞志; 吉田 俊昭; 宍戸 春美

doi:10.11150/kansenshogakuzasshi1970.56.403

Comparative Test of the Effectiveness of Clindamycin Phosphate and Lincomycin Hydrochloride on Acute Pneumonia (II)

Keiichi NAKAGAWA, Masaru KOYAMA, Katsuhito ITO, Takashi YAMAMOTO, Masami UEDA, Akira FUKUI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Katsuhiko MATSUI, Morikuni ABE, Kazuo TAKEBE, Shuichiro YOSHIDA, Katsuhiro OKAMOTO, Eiko TAKAHASHI, Shiro KOSAKA, Hitoshi YASHIRO, Yuzuru FUJIOKA, Mitsuo MASUDA, Hajime WATANABE, Seiichi MURAKAMI, Masafumi KITAOKA, Katsumi ENDO, Toyokazu TAMURA, Takeshi OSONOI, Masato HAYASHI, Chiyohiko SHINDO, Tahei MURAKAMI, Yasuro SATO, Izumi HAYASHI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yutaka KANAZAWA, Masataka KATSU, Shinji OKUI, Masakatsu HAYAKAWA, Junzaburo KABE, Ippei FUJIMORI, Yoshio KOBAYASHI, Yoshihiko TAKEDA, Kaoru OYAMA, Hiroshi OKUBO, Yuruko OKAMOTO, Yoshihiro UEDA, Keigo MAEHARA, Rinzo SOEJIMA, Yoshihito NIKI, Hiroo MORI, Kazuko YAMAZAKI, Yoshiro SAWAE, Keizo MATSUMOTO, Hiroshi SUZUKI, Masashi YAMAMOTO, Toshiaki YOSHIDA, Harumi SHISHIDO

Author information

Keiichi NAKAGAWA
Department of Internal Medicine, Tokyo Kyosai Hospital
Masaru KOYAMA
Department of Internal Medicine, Tokyo Kyosai Hospital
Katsuhito ITO
Department of Internal Medicine, Tokyo Kyosai Hospital
Takashi YAMAMOTO
Department of Internal Medicine, Tokyo Kyosai Hospital
Masami UEDA
Department of Internal Medicine, Tokyo Kyosai Hospital
Akira FUKUI
Department of Internal Medicine, Tokyo Kyosai Hospital
Akira SAITO
The Second Department of Internal Medicine, Hokkaido University, School of Medicine
Ichiro NAKAYAMA
The Second Department of Internal Medicine, Hokkaido University, School of Medicine
Masumi TOMIZAWA
The Second Department of Internal Medicine, Hokkaido University, School of Medicine
Katsuhiko MATSUI
The Second Department of Internal Medicine, Hokkaido University, School of Medicine
Morikuni ABE
The Second Department of Internal Medicine, Hokkaido University, School of Medicine
Kazuo TAKEBE
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Shuichiro YOSHIDA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Katsuhiro OKAMOTO
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Eiko TAKAHASHI
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Shiro KOSAKA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Hitoshi YASHIRO
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Yuzuru FUJIOKA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Mitsuo MASUDA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Hajime WATANABE
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Seiichi MURAKAMI
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Masafumi KITAOKA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Katsumi ENDO
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Toyokazu TAMURA
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Takeshi OSONOI
The Third Department of internal Medicine, Hirosaki University, School of Medicine
Masato HAYASHI
The Second Department of Internal Medicine, Hiraga General Hospital
Chiyohiko SHINDO
The Second Department of Internal Medicine, Hiraga General Hospital
Tahei MURAKAMI
The Second Department of Internal Medicine, Hiraga General Hospital
Yasuro SATO
The Second Department of Internal Medicine, Hiraga General Hospital
Izumi HAYASHI
Department of Respiratory Disease, Iwaki Kyoritsu General Hospital
Fusanosuke YAMASAKU
Department of Internal Medicine, Suibarago Hospital
Yasutoshi SUZUKI
Department of Internal Medicine, Suibarago Hospital
Osamu SEKINE
Department of Internal Medicine, Shinrakuen Hospital
Yoshimaru USUDA
Department of Internal Medicine, Shinrakuen Hospital
Nobuki AOKI
Department of Internal Medicine, Shinrakuen Hospital
Yutaka KANAZAWA
Department of Internal Medicine, Toyosaka Hospital
Masataka KATSU
Department of Internal Medicine, Kasumigaura National Hospital
Shinji OKUI
Department of Internal Medicine, Kasumigaura National Hospital
Masakatsu HAYAKAWA
Department of Internal Medicine, Kasumigaura National Hospital
Junzaburo KABE
Department of Respiratory Disease, National Medical Center Hospital
Ippei FUJIMORI
Department of Internal Medicine, Kawasaki Municipal Hospital
Yoshio KOBAYASHI
Department of Internal Medicine, Kawasaki Municipal Hospital
Yoshihiko TAKEDA
Department of Internal Medicine, Kawasaki Municipal Hospital
Kaoru OYAMA
Department of Internal Medicine, Toyama Prefectural Central Hospital
Hiroshi OKUBO
The First Department of Internal Medicine, Kansai Medical University
Yuruko OKAMOTO
The First Department of Internal Medicine, Kansai Medical University
Yoshihiro UEDA
The First Department of Internal Medicine, Kansai Medical University
Keigo MAEHARA
The First Department of Internal Medicine, Kansai Medical University
Rinzo SOEJIMA
Department of Internal Medicine, Kawasaki Medical College
Yoshihito NIKI
Department of Internal Medicine, Kawasaki Medical College
Hiroo MORI
Department of Internal Medicine, Kawasaki Medical College
Kazuko YAMAZAKI
Department of Internal Medicine, Kawasaki Medical College
Yoshiro SAWAE
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
Keizo MATSUMOTO
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Hiroshi SUZUKI
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Masashi YAMAMOTO
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Toshiaki YOSHIDA
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Harumi SHISHIDO
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University

Keywords: Acute pneumonia, Double-blind study, Clindamycin phosphate, Lincomycin

JOURNAL FREE ACCESS

1982 Volume 56 Issue 5 Pages 403-433

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.56.403

Details

Abstract

The therapeutic effectiveness and side effects of CLDM-P were investigated in a series of double blind studies using LCM as control in the treatment of acute pneumonia. These studies were conducted in 25 institutions throughout the country on 119 cases. Twenty-five (25) out of these cases were excepted from evaluation and 94 cases were evaluated. A dose of 600 mg of the compounds were dissolved in 200-300 ml of aqueous sugar solution or normal saline solution and given by drip infusion over an hour twice a day with a 12 hours interval.
Evaluation was made on 50 patients treated with CLDM-P and 44 with LCM. General improvement was shown in 88.0% of the CLDM-P group and 93.2% of the LCM group; both drugs proved highly effective, with no significant difference between them.
As for symptoms or clinical findings, the CLDM-P group showed significantly better improvement or improving tendency than the other in some evaluation items, probably because CLDM has higher activity than LCM. No significant difference was noted between two treatment groups in the incidences of side effects and abnormal laboratory values. It may be concluded that CLDM-P is effective in treating acute pneumonia.

Corresponding author

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