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Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

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Journal of Chemical Biology

Abstract

Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose–response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.

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Authors and Affiliations

  1. School of Engineering and Science, Centre for Nano- and functional materials, Jacobs University Bremen, Campus Ring 8, 28759, Bremen, Germany

    Nikolai Kuhnert, Farnoosh Dairpoosh, Rakesh Jaiswal, Marius Matei, Sagar Deshpande, Agnieszka Golon, Hany Nour, Hande Karaköse & Nadim Hourani

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  1. Nikolai Kuhnert
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Correspondence to Nikolai Kuhnert.

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Kuhnert, N., Dairpoosh, F., Jaiswal, R. et al. Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?. J Chem Biol 4, 109–116 (2011). https://doi.org/10.1007/s12154-011-0055-9

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  • DOI: https://doi.org/10.1007/s12154-011-0055-9

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