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Patients with Schizophrenia Do Not Demonstrate Worse Outcome After Sleeve Gastrectomy: a Short-Term Cohort Study

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Abstract

Purpose

The aim of this study was to compare surgical and psychiatric outcome and weight loss in schizophrenia patients with mentally healthy patients after sleeve gastrectomy.

Materials and Methods

A cohort study design was selected, comprising patients with schizophrenia with mentally healthy patients who underwent sleeve gastrectomy and were adherent to a follow-up at least 12 months after surgery.

Results

Seven schizophrenia (5 male, 2 female) and 59 (12 male, 47 female) mentally healthy patients were included in this study. A laparoscopic sleeve gastrectomy was performed safely in all 66 patients. The calculated excess weight loss (%EWL) showed no significant differences in both groups and reached 51.68 ± 15.84% for schizophrenia group and 60.68 ± 19.95% for mentally healthy group at 24-month follow-up (p = 0.33). The decrease in the HbA1c levels within 2 years after sleeve gastrectomy was similar in both groups (p = 0.79, 0.88, 0.82, 0.73 for surgery time, time of 6-, 12-, and 24-month follow-up respectively). The psychiatric status of the patients of the schizophrenia group was stable in all cases and no exacerbation of psychiatric symptoms was observed during time of follow-up. Furthermore, an overall significant improvement of the self-estimated mood and satisfaction was observed in both groups (Manova: f = 1.26, p < 0.0001).

Conclusions

The results 2 years after sleeve gastrectomy in stable patients with schizophrenia and after an adequate psychological evaluation were encouraging and comparable to the outcome in mentally healthy patients.

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Authors and Affiliations

  1. Department of General, Visceral and Transplant Surgery, Eberhard-Karls-University Hospital Tuebingen, Hoppe-Seyler-Str. 3-5, 72076, Tübingen, Germany

    Rami Archid, Nicole Archid, Jonas Hoffmann, Julia Hilbert, Daniel Wulff, Markus Quante, Alfred Königsrainer & Jessica Lange

  2. Department of General, Visceral and Transplant Surgery, Bad Cannstatt Hospital, Stuttgart, Germany

    Tobias Meile

  3. Department of Psychosomatic Medicine and Psychotherapy, Eberhard-Karls-University Hospital Tuebingen, Tübingen, Germany

    Martin Teufel & Michaela Muthig

  4. Clinic for Psychosomatic Medicine and Psychotherapy, University of Duisburg-Essen, LVR Clinic, Essen, Germany

    Martin Teufel

Authors
  1. Rami Archid
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  2. Nicole Archid
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  3. Tobias Meile
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  4. Jonas Hoffmann
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  5. Julia Hilbert
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  6. Daniel Wulff
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  7. Martin Teufel
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  8. Michaela Muthig
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  9. Markus Quante
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  10. Alfred Königsrainer
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  11. Jessica Lange
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Corresponding author

Correspondence to Rami Archid.

Ethics declarations

This study was approved by the local ethic committee at the University Hospital of Tübingen, Germany.

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Archid, R., Archid, N., Meile, T. et al. Patients with Schizophrenia Do Not Demonstrate Worse Outcome After Sleeve Gastrectomy: a Short-Term Cohort Study. OBES SURG 29, 506–510 (2019). https://doi.org/10.1007/s11695-018-3578-0

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  • DOI: https://doi.org/10.1007/s11695-018-3578-0

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