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Ni-catalyzed ligand-controlled divergent and selective synthesis

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Abstract

Scaffold diversity is a key feature of a compound library and plays a pivotal role in its success in biological screening. Therefore, it is highly desirable to develop efficient strategies to rapidly construct structurally distinct and diverse “privileged” molecular scaffolds, thereby giving rise to compound libraries with selective and differing biological activities. This review covers recent efforts in this emerging field of Ni-catalyzed divergent and selective synthesis, and will focus on reactions using the same substrate to generate structurally diverse molecular scaffolds by varying the ligand backbone under otherwise almost identical reaction conditions. We hope that the field will be encouraged by the progress achieved, drawing attention to the design and development of new selective catalytic systems, and revealing new modes of catalytic transformation for broader synthetic applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22171215), Hubei Provincial Outstanding Youth Fund (2022CFA092), and Guangdong Basic and Applied Basic Research Foundation (2022A1515010246).

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  1. The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, China

    Yang Ke, Wei Li, Wenfeng Liu & Wangqing Kong

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  1. Yang Ke
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Correspondence to Wangqing Kong.

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Ke, Y., Li, W., Liu, W. et al. Ni-catalyzed ligand-controlled divergent and selective synthesis. Sci. China Chem. 66, 2951–2976 (2023). https://doi.org/10.1007/s11426-023-1533-y

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