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Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas

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Abstract

An elastofibroma is a benign and rare fibrous lesion that most commonly occurs in the periscapular region. A gastrointestinal elastofibroma is extremely rare. In the present study, six cases of elastofibromas including a case in the stomach were evaluated. The gastric case revealed widely distributed lesions in the submucosal layer with perivascular fibrotic lesions (PVFLs) and some PVFLs were distributed to the skip lesions of elastofibroma. These PVFLs were also observed in all five periscapular cases and invariably contained elastic fibers which showed various degree of maturation. CD34-positive stromal cells were observed not only in elastofibromas but also in PVFLs in each case. These findings suggested the possibility of the PVFLs were the primary lesions of elastofibroma and their vascular-centric development. The percentage of the CD105-positive vessels in elastofibroma group was significantly higher than in the control group. This result indicates active neovascularization in elastofibromas.

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Acknowledgements

We would like to thank Mr. F. Mutoh and Mr. S. Nakahara for their valuable contributions to the immunohistochemical and ultrastructural studies.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology and Biodefense, Saga University Faculty of Medicine, Nabesima 5-1-1, Saga city, Saga, 849-8501, Japan

    Keita Kai, Kenichiro Kusano & Osamu Tokunaga

  2. Department of Surgery, Karatsu Red Cross Hospital, Saga, Japan

    Masashi Sakai, Masanobu Tabuchi & Seiji Yunotani

  3. Department of Surgery, Saga University Faculty of Medicine, Nabesima 5-1-1, Saga city, Saga, 849-8501, Japan

    Keita Kai & Kohji Miyazaki

Authors
  1. Keita Kai
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  2. Kenichiro Kusano
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  3. Masashi Sakai
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  4. Masanobu Tabuchi
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  5. Seiji Yunotani
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  6. Kohji Miyazaki
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  7. Osamu Tokunaga
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Correspondence to Keita Kai.

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Kai, K., Kusano, K., Sakai, M. et al. Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas. Virchows Arch 454, 181–188 (2009). https://doi.org/10.1007/s00428-008-0722-6

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  • DOI: https://doi.org/10.1007/s00428-008-0722-6

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