Skip to main content

Advertisement

SpringerLink
Log in

Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort

  • Original Paper
  • Published:
European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

Objectives

High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.

Methods

We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.

Results

The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (p < 0.01), and dyslexia and dysphasia for NRH (p = 0.01 and p = 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96–0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03–1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all p < 0.01) and less mood stabilizer prescription (p = 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index.

Conclusions

Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Availability of data and materials

The data that support the findings of this study are available from Foundation Fondamental. Restrictions apply to the availability of these data, which were used under license for this study. Data are available the corresponding author with the permission of Fondation Fondamental.

Code availability

Analyses were conducted using SAS-9.3 (SAS Statistical Institute, Cary, North Carolina).

References

  1. Kloiber S, Rosenblat JD, Husain MI et al (2020) Neurodevelopmental pathways in bipolar disorder. Neurosci Biobehav Rev 112:213–226. https://doi.org/10.1016/j.neubiorev.2020.02.005

    Article  PubMed  Google Scholar 

  2. Brandler WM, Paracchini S (2014) The genetic relationship between handedness and neurodevelopmental disorders. Trends Mol Med 20:83–90. https://doi.org/10.1016/j.molmed.2013.10.008

    Article  PubMed  PubMed Central  Google Scholar 

  3. Satz P, Green MF (1999) Atypical handedness in schizophrenia: some methodological and theoretical issues. Schizophr Bull 25:63–78

    Article  CAS  Google Scholar 

  4. Webb JR, Schroeder MI, Chee C et al (2013) Left-handedness among a community sample of psychiatric outpatients suffering from mood and psychotic disorders. SAGE Open 3:2158244013503166. https://doi.org/10.1177/2158244013503166

    Article  Google Scholar 

  5. Hirnstein M, Leask S, Rose J, Hausmann M (2010) Disentangling the relationship between hemispheric asymmetry and cognitive performance. Brain Cogn 73:119–127. https://doi.org/10.1016/j.bandc.2010.04.002

    Article  PubMed  Google Scholar 

  6. Leaver LA, Ford S, Miller CW et al (2020) Learning is negatively associated with strength of left/right paw preference in wild grey squirrels (Sciurus carolinensis). Learn Behav 48:96–103. https://doi.org/10.3758/s13420-019-00408-2

    Article  PubMed  PubMed Central  Google Scholar 

  7. Klimkeit EI, Bradshaw JL (2006) Anomalous lateralisation in neurodevelopmental disorders. Cortex J Devoted Study Nerv Syst Behav 42:113–116

    Article  Google Scholar 

  8. Darvik M, Lorås H, Pedersen AV (2018) The prevalence of left-handedness is higher among individuals with developmental coordination disorder than in the general population. Front Psychol 9:1948. https://doi.org/10.3389/fpsyg.2018.01948

    Article  PubMed  PubMed Central  Google Scholar 

  9. Nowakowska C, Sachs GS, Zarate CA et al (2008) Increased rate of non-right-handedness in patients with bipolar disorder. J Clin Psychiatry 69:866–867

    Article  Google Scholar 

  10. Ravichandran C, Shinn AK, Öngür D et al (2017) Frequency of non-right-handedness in bipolar disorder and schizophrenia. Psychiatry Res 253:267–269. https://doi.org/10.1016/j.psychres.2017.04.011

    Article  PubMed  PubMed Central  Google Scholar 

  11. Markou P, Ahtam B, Papadatou-Pastou M (2017) Elevated levels of atypical handedness in autism: meta-analyses. Neuropsychol Rev 27:258–283. https://doi.org/10.1007/s11065-017-9354-4

    Article  PubMed  Google Scholar 

  12. Burnett AC, Anderson PJ, Joseph RM et al (2018) Hand preference and cognitive, motor, and behavioral functioning in 10-year-old extremely preterm children. J Pediatr 195:279-282.e3. https://doi.org/10.1016/j.jpeds.2017.11.056

    Article  PubMed  PubMed Central  Google Scholar 

  13. Rodriguez A, Kaakinen M, Moilanen I et al (2010) Mixed-handedness is linked to mental health problems in children and adolescents. Pediatrics 125:e340-348. https://doi.org/10.1542/peds.2009-1165

    Article  PubMed  Google Scholar 

  14. Savitz J, van der Merwe L, Solms M, Ramesar R (2007) Lateralization of hand skill in bipolar affective disorder. Genes Brain Behav 6:698–705. https://doi.org/10.1111/j.1601-183X.2006.00299.x

    Article  CAS  PubMed  Google Scholar 

  15. Annett M, Moran P (2006) Schizotypy is increased in mixed-handers, especially right-handed writers who use the left hand for primary actions. Schizophr Res 81:239–246. https://doi.org/10.1016/j.schres.2005.07.033

    Article  PubMed  Google Scholar 

  16. Chapman JP, Chapman LJ (1987) Handedness of hypothetically psychosis-prone subjects. J Abnorm Psychol 96:89–93. https://doi.org/10.1037/0021-843X.96.2.89

    Article  CAS  PubMed  Google Scholar 

  17. Richardson AJ (1994) Dyslexia, handedness and syndromes of psychosis-proneness. Int J Psychophysiol 18:251–263. https://doi.org/10.1016/0167-8760(94)90011-6

    Article  CAS  PubMed  Google Scholar 

  18. Stefanis NC, Vitoratou S, Smyrnis N et al (2006) Mixed handedness is associated with the Disorganization dimension of schizotypy in a young male population. Schizophr Res 87:289–296. https://doi.org/10.1016/j.schres.2006.04.021

    Article  PubMed  Google Scholar 

  19. Orr KGD, Cannon M, Gilvarry CM et al (1999) Schizophrenic patients and their first-degree relatives show an excess of mixed-handedness. Schizophr Res 39:167–176. https://doi.org/10.1016/S0920-9964(99)00071-7

    Article  CAS  PubMed  Google Scholar 

  20. Kim D, Raine A, Triphon N, Green MF (1992) Mixed handedness and features of schizotypal personality in a nonclinical sample. J Nerv Ment Dis 180:133–135. https://doi.org/10.1097/00005053-199202000-00012

    Article  CAS  PubMed  Google Scholar 

  21. Morris-Rosendahl DJ, Crocq M-A (2020) Neurodevelopmental disorders—the history and future of a diagnostic concept. Dialogues Clin Neurosci 22:65–72. https://doi.org/10.31887/DCNS.2020.22.1/macrocq

    Article  PubMed  PubMed Central  Google Scholar 

  22. van Dyck LI, Pittman BP, Blumberg HP (2012) Non-right-handedness in adolescents and adults with bipolar disorder. Bipolar Disord 14:571–572. https://doi.org/10.1111/j.1399-5618.2012.01037.x

    Article  PubMed  PubMed Central  Google Scholar 

  23. Fasmer OB, Akiskal HS, Hugdahl K, Oedegaard KJ (2008) Non-right-handedness is associated with migraine and soft bipolarity in patients with mood disorders. J Affect Disord 108:217–224. https://doi.org/10.1016/j.jad.2007.10.028

    Article  PubMed  Google Scholar 

  24. Wang B, Li T, Zhou M et al (2018) The abnormality of topological asymmetry in hemispheric brain anatomical networks in bipolar disorder. Front Neurosci 12:618. https://doi.org/10.3389/fnins.2018.00618

    Article  PubMed  PubMed Central  Google Scholar 

  25. Ho NF, Li Z, Ji F et al (2017) Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder. J Psychiatry Neurosci JPN 42:242–251. https://doi.org/10.1503/jpn.160090

    Article  PubMed  Google Scholar 

  26. Deep-Soboslay A, Hyde TM, Callicott JP et al (2010) Handedness, heritability, neurocognition and brain asymmetry in schizophrenia. Brain J Neurol 133:3113–3122. https://doi.org/10.1093/brain/awq160

    Article  Google Scholar 

  27. Geschwind N, Galaburda AM (1985) Cerebral lateralization. Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Arch Neurol 42:428–459

    Article  CAS  Google Scholar 

  28. Llaurens V, Raymond M, Faurie C (2009) Why are some people left-handed? An evolutionary perspective. Philos Trans R Soc Lond B Biol Sci 364:881–894. https://doi.org/10.1098/rstb.2008.0235

    Article  CAS  PubMed  Google Scholar 

  29. Henry C, Etain B, Mathieu F et al (2011) A French network of bipolar expert centres: a model to close the gap between evidence-based medicine and routine practice. J Affect Disord 131:358–363. https://doi.org/10.1016/j.jad.2010.11.013

    Article  PubMed  Google Scholar 

  30. Henry C, Etain B, Godin O et al (2015) Bipolar patients referred to specialized services of care: not resistant but impaired by sub-syndromal symptoms. Results from the FACE-BD cohort. Aust N Z J Psychiatry 49:898–905. https://doi.org/10.1177/0004867415585582

    Article  PubMed  Google Scholar 

  31. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry J Ment Sci 134:382–389

    Article  CAS  Google Scholar 

  32. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435. https://doi.org/10.1192/bjp.133.5.429

    Article  CAS  PubMed  Google Scholar 

  33. Yatham LN, Torres IJ, Malhi GS et al (2010) The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord 12:351–363. https://doi.org/10.1111/j.1399-5618.2010.00830.x

    Article  PubMed  Google Scholar 

  34. Delis DC, Kramer JH, Kaplan E, Ober BA (2000) California verbal learning test-adult version, 2nd edn. Psychological Corporation, San Antonio

    Google Scholar 

  35. Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276. https://doi.org/10.2466/pms.1958.8.3.271

    Article  Google Scholar 

  36. Lezak MD, Howieson DB, & Loring DW (2004) Neuropsychological Assessment (4th ed.). New York: Oxford University Press, pp 647–693

    Google Scholar 

  37. Conners CK (2004) Multi health systems. Conners' continuous performance test II: Technical guide for software manual. New York: Multi-Health Systems

    Google Scholar 

  38. Paquette D, Laporte L, Bigras M, Zoccolillo M (2004) Validation de la version française du CTQ et prévalence de l’histoire de maltraitance 1. Sant233 Ment Au Qu233bec 29:201–220. https://doi.org/10.7202/008831ar

    Article  Google Scholar 

  39. Romo L, Legauffre C, Mille S et al (2010) Psychometric properties of the French version of the Wender Utah Rating Scale and Brown’s Attention Deficit Disorders Scale for adults. L’Encephale 36:380–389. https://doi.org/10.1016/j.encep.2009.12.005

    Article  CAS  PubMed  Google Scholar 

  40. Bendel RB, Afifi AA (1977) Comparison of stopping rules in forward “stepwise” regression. J Am Stat Assoc 72:46–53. https://doi.org/10.1080/01621459.1977.10479905

    Article  Google Scholar 

  41. Bursac Z, Gauss CH, Williams DK, Hosmer DW (2008) Purposeful selection of variables in logistic regression. Source Code Biol Med 3:17. https://doi.org/10.1186/1751-0473-3-17

    Article  PubMed  PubMed Central  Google Scholar 

  42. Mickey RM, Greenland S (1989) The impact of confounder selection criteria on effect estimation. Am J Epidemiol 129:125–137. https://doi.org/10.1093/oxfordjournals.aje.a115101

    Article  CAS  PubMed  Google Scholar 

  43. Bender R, Lange S (2001) Adjusting for multiple testing–when and how? J Clin Epidemiol 54:343–349

    Article  CAS  Google Scholar 

  44. Hadland SE, Knight JR, Harris SK (2015) Medical marijuana: review of the science and implications for developmental behavioral pediatric practice. J Dev Behav Pediatr JDBP 36:115–123. https://doi.org/10.1097/DBP.0000000000000129

    Article  PubMed  Google Scholar 

  45. Anker E, Haavik J, Heir T (2020) Alcohol and drug use disorders in adult attention-deficit/hyperactivity disorder: prevalence and associations with attention-deficit/hyperactivity disorder symptom severity and emotional dysregulation. World J Psychiatry 10:202–211. https://doi.org/10.5498/wjp.v10.i9.202

    Article  PubMed  PubMed Central  Google Scholar 

  46. Mallet J, Ramoz N, Le Strat Y et al (2017) Heavy cannabis use prior psychosis in schizophrenia: clinical, cognitive and neurological evidences for a new endophenotype? Eur Arch Psychiatry Clin Neurosci. https://doi.org/10.1007/s00406-017-0767-0

    Article  PubMed  Google Scholar 

  47. Decina P, Kestenbaum CJ, Farber S et al (1983) Clinical and psychological assessment of children of bipolar probands. Am J Psychiatry 140:548–553. https://doi.org/10.1176/ajp.140.5.548

    Article  CAS  PubMed  Google Scholar 

  48. Dane S, Balci N (2007) Handedness, eyedness and nasal cycle in children with autism. Int J Dev Neurosci Off J Int Soc Dev Neurosci 25:223–226. https://doi.org/10.1016/j.ijdevneu.2007.03.005

    Article  Google Scholar 

  49. Preti A, Sardu C, Piga A (2007) Mixed-handedness is associated with the reporting of psychotic-like beliefs in a non-clinical Italian sample. Schizophr Res 92:15–23. https://doi.org/10.1016/j.schres.2007.01.028

    Article  PubMed  Google Scholar 

  50. Crow TJ, Chance SA, Priddle TH et al (2013) Laterality interacts with sex across the schizophrenia/bipolarity continuum: an interpretation of meta-analyses of structural MRI. Psychiatry Res 210:1232–1244. https://doi.org/10.1016/j.psychres.2013.07.043

    Article  PubMed  Google Scholar 

  51. Mazoyer B, Zago L, Jobard G et al (2014) Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness. PLoS ONE 9:e101165. https://doi.org/10.1371/journal.pone.0101165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Somers M, Aukes MF, Ophoff RA et al (2015) On the relationship between degree of hand-preference and degree of language lateralization. Brain Lang 144:10–15. https://doi.org/10.1016/j.bandl.2015.03.006

    Article  PubMed  Google Scholar 

  53. Tzourio-Mazoyer N, Marie D, Zago L et al (2015) Heschl’s gyrification pattern is related to speech-listening hemispheric lateralization: FMRI investigation in 281 healthy volunteers. Brain Struct Funct 220:1585–1599. https://doi.org/10.1007/s00429-014-0746-4

    Article  CAS  PubMed  Google Scholar 

  54. Sommer I, Ramsey N, Kahn R et al (2001) Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. Br J Psychiatry J Ment Sci 178:344–351

    Article  CAS  Google Scholar 

  55. Bishop DVM (2013) Cerebral asymmetry and language development: cause, correlate or consequence? Science 340:1230531. https://doi.org/10.1126/science.1230531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Botha H, Duffy JR, Whitwell JL et al (2018) Non-right handed primary progressive apraxia of speech. J Neurol Sci 390:246–254. https://doi.org/10.1016/j.jns.2018.05.007

    Article  PubMed  PubMed Central  Google Scholar 

  57. Ecevitoglu A, Soyman E, Canbeyli R, Unal G (2020) Paw preference is associated with behavioural despair and spatial reference memory in male rats. Behav Processes 180:104254. https://doi.org/10.1016/j.beproc.2020.104254

    Article  PubMed  Google Scholar 

  58. Abdolmaleky HM, Gower AC, Wong C-K et al (2019) Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder. Am J Med Genet Part B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 180:138–149. https://doi.org/10.1002/ajmg.b.32691

    Article  CAS  Google Scholar 

  59. Hirnstein M, Hugdahl K (2014) Excess of non-right-handedness in schizophrenia: meta-analysis of gender effects and potential biases in handedness assessment. Br J Psychiatry J Ment Sci 205:260–267. https://doi.org/10.1192/bjp.bp.113.137349

    Article  Google Scholar 

  60. Wang Q, Zhang J, Liu Z et al (2018) “Brain connectivity deviates by sex and hemisphere in the first episode of schizophrenia”-a route to the genetic basis of language and psychosis? Schizophr Bull. https://doi.org/10.1093/schbul/sby061

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Authors express all our thanks to the nurses, and to the patients who were included in the present study. Authors thank Hakim Laouamri and his team for the development of the FACE-BD computer interface, data management, quality control and regulatory aspects. J. Mallet is a member of Labex BioPsy.

List of FondaMental Advanced Center of Expertise (FACE-BD) collaborators: FACE-BD Clinical Coordinating Center (Fondation FondaMental); B. Etain, E. Olié, M. Leboyer. FACE-BD Data Coordinating Center (Fondation FondaMental); V. Barteau, S. Bensalem, O. Godin, H. Laouamri, and K. Souryis. FACE-BD Clinical Sites and Principal Collaborators in France; AP-HP. DHU PePSY, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires H Mondor, Créteil; S. Hotier, A. Pelletier, N. Drancourt, J. P. Sanchez, E. Saliou, C. Hebbache, J. Petrucci, L. Willaume and E. Bourdin; AP-HP, GH Saint-Louis–Lariboisière–Fernand Widal, Pôle Neurosciences, Paris; F. Bellivier, M. Carminati, B. Etain, E. Marlinge and J. Meheust; Hôpital C. Perrens, Centre Expert Trouble Bipolaire, Service de Psychiatrie Adulte, Pôle 3-4-7, Bordeaux; B. Antoniol, A. Desage, S. Gard, A. Jutant, K. Mbailara, I. Minois, and L. Zanouy; Département d’Urgence et Post Urgence Psychiatrique, CHRU Montpellier, Montpellier; C. Abettan, L. Bardin, A. Cazals, P. Courtet, B. Deffinis, D. Ducasse, M. Gachet, A. Henrion, E. Martinerie, F. Molière, B. Noisette, E. Olié and G. Tarquini; Pôle de Psychiatrie, addictologie et pédopsychiatrie, Hôpital Sainte Marguerite, Assistance Publique Hôpitaux de Marseille; J. M. Azorin, R. Belzeaux, N. Correard, I. Muraccioli, F. Groppi, L. Lescalier, M. Rebattu and N. Viglianese; Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy; R. Cohen, J. P. Kahn, M. Milazzo, and O. Wajsbrot-Elgrabli; Clinique Universitaire de Psychiatrie, CHU de Grenoble et des Alpes, Grenoble; T. Bougerol, B. Fredembach, A. Suisse, L. Tassan, A. Pouchon, and M. Polosan; Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d’adultes et d’addictologie, Le Chesnay; A. S. Cannavo, A. Crea, V. Feuga, A. M. Galliot, N. Kayser, C. Passerieux, and P. Roux; Service de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco; V. Aubin, I. Cussac, M. A. Dupont, J. Loftus, and I. Medecin; AHPH, Departement de Psychiatrie, Hopital Louis Mourier, Colombes, France; A. Bing, C. Dubertret and N. Mazer; CHU de Clermont-Ferrand, Centre Expert Troubles Bipolaires FondaMental, Clermont-Ferrand, France: P. M. Llorca, L. Samalin, L. Foures, D. Lacelle, S. Pires, C. Doriat and O. Blanc.

Funding

This work was funded by AP-HP (Assistance Publique des Hôpitaux de Paris), Fondation FondaMental (RTRS Santé Mentale), by the “Investissements d’Avenir” programs managed by the Agence Nationale de Recherche (ANR), France under references ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut National de la Santé et de la Recherche Médicale).

Author information

Authors and Affiliations

  1. Fondation Fondamental, Créteil, France

    Jasmina Mallet, Ophélia Godin, Nicolas Mazer, Yann Le Strat, Frank Bellivier, Raoul Belzeaux, Bruno Etain, Guillaume Fond, Sébastien Gard, Chantal Henry, Marion Leboyer, Pierre-Michel Llorca, Joséphine Loftus, Emilie Olié, Christine Passerieux, Mircea Polosan, Paul Roux & Caroline Dubertret

  2. Faculté de médecine, AP-HP, Department of Psychiatry, Université de Paris, Louis Mourier Hospital, CHU Louis Mourier, 178 rue des Renouillers, 92700, Colombes, France

    Jasmina Mallet, Nicolas Mazer, Yann Le Strat, Raymund Schwan & Caroline Dubertret

  3. INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, Paris, France

    Jasmina Mallet, Nicolas Mazer, Yann Le Strat & Caroline Dubertret

  4. UMR_S955, UPEC, Créteil, France Inserm, Université Paris-Est, U955, Equipe 15 Psychiatrie génétique, Créteil, France

    Ophélia Godin & Marion Leboyer

  5. AP-HP, GH Saint-Louis—Lariboisière—Fernand Widal, Pôle Neurosciences Tête et Cou, INSERM UMRS 1144, University Paris Diderot, Paris, France

    Frank Bellivier & Bruno Etain

  6. AP-HM, Department of Psychiatry, Marseille, France

    Raoul Belzeaux

  7. AP-HM, Aix-Marseille University, School of Medicine—La Timone Medical Campus, EA 3279: CEReSS—Health Service Research and Quality of Life Center, 27 Boulevard Jean Moulin, 13005, Marseille, France

    Guillaume Fond

  8. Centre Expert Troubles Bipolaires, Service de Psychiatrie Adulte, Hôpital Charles-Perrens, Bordeaux, France

    Sébastien Gard

  9. Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie and Neurosciences, 75014, Paris, France

    Chantal Henry

  10. CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, EA 7280, Clermont-Ferrand, France

    Pierre-Michel Llorca

  11. Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco, France

    Joséphine Loftus

  12. Department of Emergency Psychiatry and Acute Care, CHU Montpellier, INSERM U1061, Montpellier University, Montpellier, France

    Emilie Olié

  13. Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay, France

    Christine Passerieux & Paul Roux

  14. Université Grenoble Alpes, Inserm, U1216, Grenoble Institut des Neurosciences, CHU Grenoble Alpes, 38000, Grenoble, France

    Mircea Polosan

  15. CHRU de Nancy et Pôle de Psychiatrie et Psychologie Clinique, Université de Lorraine, Centre Psychothérapique de Nancy, Nancy, France

    Raymund Schwan

  16. AP-HP, Hôpital H. Mondor-A. Chenevier, Pôle de psychiatrie, Créteil, France

    Ophélia Godin & Marion Leboyer

  17. Fondation de Cooperation Scientifique, Fondation FondaMental, Créteil, France

    Marion Leboyer

  18. INT-UMR7289, CNRS Aix Marseille University, Marseille, France

    Raoul Belzeaux

  19. CESP, INSERM, Université Paris Saclay, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France

    Christine Passerieux & Paul Roux

Authors
  1. Jasmina Mallet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ophélia Godin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicolas Mazer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yann Le Strat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Frank Bellivier
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Raoul Belzeaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bruno Etain
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Guillaume Fond
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sébastien Gard
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Chantal Henry
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Marion Leboyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Pierre-Michel Llorca
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Joséphine Loftus
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Emilie Olié
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Christine Passerieux
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Mircea Polosan
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Raymund Schwan
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Paul Roux
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Caroline Dubertret
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group

  • B. Etain
  • , E. Olié
  • , M. Leboyer
  • , V. Barteau
  • , S. Bensalem
  • , O. Godin
  • , H. Laouamri
  • , K. Souryis
  • , S. Hotier
  • , A. Pelletier
  • , N. Drancourt
  • , J. P. Sanchez
  • , E. Saliou
  • , C. Hebbache
  • , J. Petrucci
  • , L. Willaume
  • , E. Bourdin
  • , F. Bellivier
  • , M. Carminati
  • , B. Etain
  • , E. Marlinge
  • , J. Meheust
  • , B. Antoniol
  • , A. Desage
  • , S. Gard
  • , A. Jutant
  • , K. Mbailara
  • , I. Minois
  • , L. Zanouy
  • , C. Abettan
  • , L. Bardin
  • , A. Cazals
  • , P. Courtet
  • , B. Deffinis
  • , D. Ducasse
  • , M. Gachet
  • , A. Henrion
  • , E. Martinerie
  • , F. Molière
  • , B. Noisette
  • , E. Olié
  • , G. Tarquini
  • , J. M. Azorin
  • , R. Belzeaux
  • , N. Correard
  • , I. Muraccioli
  • , F. Groppi
  • , L. Lescalier
  • , M. Rebattu
  • , N. Viglianese
  • , R. Cohen
  • , J. P. Kahn
  • , M. Milazzo
  • , O. Wajsbrot-Elgrabli
  • , T. Bougerol
  • , B. Fredembach
  • , A. Suisse
  • , L. Tassan
  • , A. Pouchon
  • , M. Polosan
  • , A. S. Cannavo
  • , A. Crea
  • , V. Feuga
  • , A. M. Galliot
  • , N. Kayser
  • , C. Passerieux
  • , P. Roux
  • , V. Aubin
  • , I. Cussac
  • , M. A. Dupont
  • , J. Loftus
  • , I. Medecin
  • , A. Bing
  • , C. Dubertret
  • , N. Mazer
  • , P. M. Llorca
  • , L. Samalin
  • , L Foures
  • , D. Lacelle
  • , S. Pires
  • , C. Doriat
  •  & O. Blanc

Contributions

All authors acquired the data, which JM, OG, CD analyzed. OG completed the statistical analyses. JM had the idea and wrote the article, which all authors reviewed. All authors approved the final version to be published and can certify that no other individuals not listed as authors have made substantial contributions to the paper.

Corresponding author

Correspondence to Jasmina Mallet.

Ethics declarations

Conflict of interest

The authors report no financial or other relationship relevant to the subject of this article, including the contributing members of the FACE-BD Group.

Ethics approval

This study has been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Consent to participate

All persons gave their informed consent prior to their inclusion in the study.

Consent for publication

All authors gave their consent for final publication.

Additional information

The members of the FondaMental Advanced Center of Expertise (FACE-BD) are listed in acknowledgements section.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mallet, J., Godin, O., Mazer, N. et al. Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort. Eur Arch Psychiatry Clin Neurosci 272, 827–838 (2022). https://doi.org/10.1007/s00406-021-01314-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00406-021-01314-3

Keywords

Search

Navigation