Standardized guinea pig model for Q fever vaccine reactogenicity
Fig 9
Zone of erythema and histopathological scores after antigenic challenge of i.n. sensitized guinea pigs.
Data are presented for each inoculation group (saline (n = 4), Cb9M: C. burnetii Nine Mile, i.n.: intranasal, (n = 9)). Coxevac challenge (2 μg delivered i.d.) was performed at day 42 p.i. (A) Histopathological scoring (0–5) is as noted in Table 1, (B) zone of erythema (mm). Error bars represent group mean and standard deviations. **Group means were statistically different for both histological scores and erythema (P value 0.002, 0.002 respectively, assessed by one-sided t test).