Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway
Fig 9
Scheme of SFN-mediated inhibition of HCV replication.
SFN induces PI3K phosphorylation and subsequently triggers Nrf2 nuclear translocation to activate HO-1 expression leading to biliverdin production against HCV replication by the induction of antiviral IFN responses and suppression of HCV NS3/4A protease activity.