Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy
Fig 9
Interaction between HLX10 and hPD-1.
(a) HLX10 Fab adopts a typical immunoglobulin fold structure. Heavy chain and light chain are colored in lime and deep teal, respectively. Intra-molecular disulfide bonds are shown in magenta sticks. (b) Side view of binding interface between HLX10 and hPD-1. hPD-1 is represented as surface in white, with BC loop, C’D loop and FG loop in light orange, light blue and light green, respectively. HCDR1, HCDR2 and HCDR3 loops are colored in yellow, orange, and red, respectively, while LCDR1, LCDR2 and LCDR3 loops are colored in blue, green, and magenta, respectively. (c, d) Interaction within interface of CDRs loop of heavy chain and hPD-1. Arg86 of hPD-1 is involved in several hydrogen bonds and salt bridges with HLX10.