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Food restriction promotes damage reduction in rat models of type 2 diabetes mellitus

Fig 8

Oxidative stress.

Effects of food restriction on the plasmatic oxidative status of type 2 diabetic rats. (A) Protein carbonyl groups, (B) Thiol groups and (C) Total antioxidant capacity (TAC). Oxidative status was assessed at the end of the food restriction period as described in Methods. CC, controls; CCR, controls under food restriction; DEC, diabetic (cafeteria-style diet) rats; DER, diabetic (cafeteria-style diet) rats under food restriction; DNC, diabetic (nicotinamide) rats; DNR, diabetic (nicotinamide) rats under food restriction. Results expressed as mean±SE (n = 4-5/group). *a p<0.05 vs CC; b p<0.05 vs DEC; c p<0.05 vs DNC. One-way ANOVA and Tukey’s post-hoc test analysis.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0199479.g008