Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin
Figure 8
TRH increases cytokeratin 6 but not involucrin expression in human skin punch wounds.
(A) Representative images indicated cytokeratin 6 (CK6) expression in control, 5 ng/mL and 10 ng/mL TRH-treated human skin punch wound sections, 6 Days post-wounding. The white-hatched line demarcates new epithelial tongue. (B) Representative images indicating involucrin (Inv) expression in control, 5 ng/mL and 10 ng/mL TRH-treated human skin punch wound sections, 6 Days post-wounding. The white-hatched line demarcates new epithelial tongue. (C) Quantification of involucrin immunoreactivity in the new epithelial tongues indicated in (A). (D) Quantification of CK6 immunoreactivity in the new epithelial tongues indicated in (B). Data are mean ± SEM of 4 female donors. Significance relative to control data at the same time-point denoted by **P<0.01, ***P<0.001.