Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat
Figure 7
Effect of KC depletion on the expression of TNF-α, IL-6, and activation of STAT-3 protein in liver tissue after PH.
ELISA was performed on supernatants from liver tissue homogenates (A, B). Western blot analysis of total and phosphorylated STAT3, including β-actin as a loading control (C). KC depletion reduced hepatic levels of TNF-α and IL-6, and reduced STAT3 activation. (Data represent mean ± SD, n = 4–5. * indicates significant difference when compared to control group, P<0.05; ** P<0.01).