Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells
Figure 7
Therapeutic effect of anti-CD44R1 fully human mAb in the tumor neutralization model.
Tumor neutralization model was adopted. ME180 human tumor cells (1.0×106) with or without mAb (50 µg/site) in 200 µl of PBS were subcutaneously inoculated into the right dorsal flank of each animal. The size of each tumor formed was periodically measured, and tumor volume (mm3) was calculated by the formula 0.4×(length)×(width)2. Results were analyzed statistically by two-way ANOVA tests with repeated measures.