Cdk2 Is Required for p53-Independent G2/M Checkpoint Control
Figure 7
The proposed role of Cdk2 in the p53-independent regulation of Cdk1.
Cdk2 directly phosphorylates at least two proteins, ATRIP and Cdc6, that directly regulate the G2-M transition via the ATR-Chk1-Cdc25A pathway. The activity of Cdk1 is independently inhibited upon activation of the p53-p21 pathway, which is defective in many cancer cells. See text for additional details.