Perturbation of BRMS1 interactome reveals pathways that impact metastasis
Fig 7
Phosphorylation at S237 contributes to the anti-metastatic phenotype of BRMS1 and alters BRMS1 protein interactions.
BRMS1 associates with Sin3/HDAC complex members as well as other proteins which are not part of the chromatin remodeling complexes. We hypothesize that BRMS1 phenotypes are determined by the proteins with which it interacts but cannot yet ascribe a specific cause-effect relationship responsible for metastasis or migratory suppression.