The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Figure 6
Influence of Nsp1 on Interleukin promoters.
HEK293 cells were transiently cotransfected with interleukin reporter plasmids IL2 luc (A), IL4 luc (B), IL8 luc (C) and expression plasmids encoding NFAT3, CnA and either SARS-CoV Nsp1fl or the empty plasmid vector. All experiments were also done with an additional overexpression of the Calcipressin RCAN3. After transfection cells were cultured in absence or with the calcineurin stimulators PMA/Io. and the inhibitor CspA. * P<0.05; ** P<0.01.