Noise-induced scaling in skull suture interdigitation
Fig 6
Direct observation of the intrinsic noise of the osteogenic signal in a newborn mouse skull.
(a) Experimental system setup. A newborn skull of an ERK-FRET transgenic mice was dissected and then set on the glass bottom dish, which was suitable for organ culture. (b) Brightfield Image of the observation area. We chose posterior fontanelle region for observation. Observation areas in (c-f) is shown by black box. Scale bar = 100 μm. (c) Spatial distribution of the FRET signal u (CFP/YFP ratio) at specific timepoint. (d) Fourier transformation of u(x, t). There was no specific characteristic in the distribution, indicating the noise was white noise. (e) Time course of FRET signal intensity at a specific line. The signal showed fluctuation. (f) Fourier transformation of (e) at single point. No specific trend was observed, indicating that the spatial noise could be regarded as white noise.