Standardized guinea pig model for Q fever vaccine reactogenicity
Fig 6
Representative histopathological scoring.
Representative photomicrographs of guinea pig skin inoculation sites for the histological scoring criteria used in the study. Numbers represent the histological scores of 0–5. 1) Arrows, multiple small aggregates of macrophage dominated inflammation in the deep dermis. 2) Arrow, linear infiltrate in deep dermis with extension into the panniculus muscle. 3) Arrows, more extensive macrophage dominated inflammation with extension through the dermis; Arrowhead, increased frequency of lymphocytic inflammation. 4) Arrow, deep dermis is effaced by dense inflammation; Arrowhead, majority of the dermis is replaced by macrophage dominated inflammation. 5) Arrow, skin is replaced by pyogranulomatous inflammation; Arrowhead, central area of necrosis contains an abundance of neutrophils.