SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A
Fig 6
SB-224289 Protects Against Theopapuamide, but Not Other Depsipeptides.
A. The structure of several depsipeptides are shown. For each of these compounds, 1x104 cells/ml were treated with serially diluted concentrations of SB-224289 (SB) and were incubated for 3 hours at 37°C. Following this incubation, B. 3 μg/ml valinomycin (VA), C. 15 μg/ml kahalalide F (KF), or D. 6 μg/ml theopapuamide (TA) was added and further allowed to incubate overnight. Optical density (OD) was read at 600 nm the next day as a measure of cell survival.