Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease
Fig 6
Total Cholesterol and GSLs accumulate in macrophages exposed to U18666A.
(A) total cholesterol, (B) ceramide, (C) sphingosine, (D) glucosylceramide (GlcCer), (E) dihydro-ceramide (Dihydro-Cer), and (F) lactosylceramide (LacCer) levels in RAW264.7 murine macrophages exposed to 1, 5 and 10 μM of U18666A for 24 h. Data (n = 3, mean ± S.E.M.) were analysed using an unpaired t-test. * P < 0.05, ** P < 0.01 and *** P < 0.001 from DMSO control.