A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum
Figure 6
HPLC-MS elution profiles of the internal standard reserpine and the highest abundant identified peptides.
Total ion chromatogram (TIC, black) and normalized extracted ion chromatograms (EIC, colored) of the protonated molecule ([M+H]+ with 5 ppm accuracy) of the used internal standard reserpine (A), the four highest abundant cyclic tetrapeptides 1 (B), 2 (C), 3 (D), 4 (E) and linear tetrapeptides 11–13 (F), 14–16 (G), 17–19 (H), 20–22 (I) present in the culture broth of P. chrysogenum.