A miRNA Signature of Prion Induced Neurodegeneration
Figure 6
Functional relationships of de-regulated immune response-related genes in the brains of mice infected with scrapie and the putative transcription regulator genes that are targets of miRNAs similarly de-regulated.
This biological network illustrates the potential for indirect regulation of immune-response related genes by miRNAs via modulation of transcriptional regulators. Nodes colored in red denote up-regulated genes in mouse scrapie whereas green denotes down-regulated genes. Nodes with an orange border denote the putative targets of miRNAs deregulated in mouse scrapie.