Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations
Fig 6
Co-localization between HEALS DMA% association signal (rs4919687) and AS3MT eQTLs in multiple tissues.
We observe evidence of co-localization in 21 GTEx tissue types, with four example tissue types shown in Panel A (aorta, adipose-visceral omentum, lung, and nerve-tibial). The low efficiency (low DMA%) allele at rs4919687 is consistently associated with lower AS3MT expression in all tissues for which co-localization was observed.