Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma
Figure 6
Treatment-related implications for dynamic oncogene expression in rhabdomyosarcoma in vivo.
(A) Kaplan-Meier survival analysis for disease-free survival of mice implanted with pre-irradiated (10Gy) primary murine aRMS tumor cells treated with Pax3:Foxo1a siRNA (siY) or control siRNA (siC), n = 5 animals per cohort. The p value for the difference between siY and siC groups receiving radiation was 0.02. (B) Diagrammatic representation of results in (A).