Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys
Fig 6
IFN-α is upregulated under hypoxic conditions in Kl−/− mice.
(A) Western blot analysis demonstrating IFN-α expression in WT and Kl−/− mice. Protein levels were normalized to β-actin levels (n = 5 in each group). (B) Representative immunohistochemical staining images showing IFN-α expression in WT and Kl−/− mice. Values are mean ± SD. *P < 0.05, **P < 0.01. Bar = 100 μm.