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Concomitant Detection of HER2 Protein and Gene Alterations by Immunohistochemistry (IHC) and Silver Enhanced In Situ Hybridization (SISH) Identifies HER2 Positive Breast Cancer with and without Gene Amplification

Figure 6

Correlation of HER2 amplification status by SISH in IHC score 3+ tumors with overall survival.

Overall survival of IHC score 3+ tumors was independent from amplification status by SISH in this cohort (Kaplan Meier curves).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0105961.g006