Annexin A1 on the Surface of Early Apoptotic Cells Suppresses CD8+ T Cell Immunity
Figure 6
Annexin A1 inhibits DC activation in vivo.
Apoptotic, mOVA-expressing Drosophila Schneider cells (aS2-mOVA) transfected with annexin A1 (AnxA1) or a control plasmid (Ctrl) were injected into mice. After 2 days, DC in lymph nodes of naïve (−) and S2-injected mice were analyzed for CD40 and CD86 expression by flow cytometry. Shown are quantifications of the MFI for CD40 and CD86 of total lymph node cells gated on CD11c+ and MHC class II+ cells *P<0.05 (n = 7). Data are representative of 3 independent experiments.