Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation
Figure 6
Ectopic fat accumulation in liver and skeletal muscle in Bmal1 -/- mice.
All tissue samples were excised at ZT10. (A) Representative morphology of the livers from control mice and Bmal1 -/- mice fed a HFD for 5 weeks. (B) Representative oil red O staining of liver tissue samples isolated from male control mice and Bmal1 -/- mice fed either a RD or HFD for 5 weeks. (C and D) Triglyceride (TG) contents in the liver (C) and skeletal muscle (D) from male control mice and Bmal1 -/- mice fed a RD or HFD for 5 weeks. Data represent the means ± SEM (n = 8 for each genotype and treatment). Asterisks indicate significant differences (P<0.05).